Seroatlas · Human Serome Atlas

SLC25A32

Solute carrier family 25 member 32

Also known as: MFTC, S2532_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H2D1
Gene
SLC25A32
Ensembl
ENSG00000164933
Chromosome
8
Canonical length
315 aa
Protein class
Disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Mitochondria

OverviewNCBI Gene

This gene encodes a member of the P(I/L)W subfamily of mitochondrial carrier family transport proteins. The encoded protein transports folate across the inner mitochondrial membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2013]

Canonical amino-acid sequenceUniProt

315 residues, UniProt reviewed canonical sequence.

>Q9H2D1|SLC25A32
     1  MTGQGQSASG SSAWSTVFRH VRYENLIAGV SGGVLSNLAL HPLDLVKIRF AVSDGLELRP
    61  KYNGILHCLT TIWKLDGLRG LYQGVTPNIW GAGLSWGLYF FFYNAIKSYK TEGRAERLEA
   121  TEYLVSAAEA GAMTLCITNP LWVTKTRLML QYDAVVNSPH RQYKGMFDTL VKIYKYEGVR
   181  GLYKGFVPGL FGTSHGALQF MAYELLKLKY NQHINRLPEA QLSTVEYISV AALSKIFAVA
   241  ATYPYQVVRA RLQDQHMFYS GVIDVITKTW RKEGVGGFYK GIAPNLIRVT PACCITFVVY
   301  ENVSHFLLDL REKRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC25A32 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • liver: 17 nTPM
  • lymph node: 16 nTPM
  • urinary bladder: 14 nTPM
  • bone marrow: 14 nTPM
  • adipose tissue: 13 nTPM
  • spleen: 12 nTPM

Single-cell type

  • oligodendrocytes: 53 nCPM
  • microglia: 52 nCPM
  • podocytes: 43 nCPM
  • oligodendrocyte progenitor cells: 40 nCPM
  • distal convoluted tubule cells: 37 nCPM
  • brain excitatory neurons: 36 nCPM

Immune cell

  • MAIT T-cell: 7.3 nTPM
  • memory B-cell: 7 nTPM
  • memory CD8 T-cell: 6.9 nTPM
  • naive CD8 T-cell: 6.7 nTPM
  • naive CD4 T-cell: 6.5 nTPM
  • memory CD4 T-cell: 6.4 nTPM

Brain region

  • white matter: 9.9 nTPM
  • spinal cord: 8.1 nTPM
  • hypothalamus: 7.9 nTPM
  • medulla oblongata: 7.8 nTPM
  • midbrain: 7.7 nTPM
  • pons: 7.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC25A32.

Disease | AllUniProt

Conditions SLC25A32 is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.32
gnomAD pLI
0
gnomAD missense Z
0.37
DepMap mean gene effect
0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 18% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC25A32 as an antibody target. Whether an autoantibody or antibody against SLC25A32 could matter depends on whether native SLC25A32 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC25A32 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC25A32 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC25A32. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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