SLC25A29

Protein identityUniProt · HPA

UniProt accession

Q8N8R3

Gene

SLC25A29

Ensembl

ENSG00000197119

Chromosome

14

Canonical length

303 aa

Protein class

Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a nuclear-encoded mitochondrial protein that is a member of the large family of solute carrier family 25 (SLC25) mitochondrial transporters. The members of this superfamily are involved in numerous metabolic pathways and cell functions. This gene product was previously reported to be a mitochondrial carnitine-acylcarnitine-like (CACL) translocase (PMID:128829710) or an ornithine transporter (designated ORNT3, PMID:19287344), however, a recent study characterized the main role of this protein as a mitochondrial transporter of basic amino acids, with a preference for arginine and lysine (PMID:24652292). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014]

Canonical amino-acid sequenceUniProt

303 residues, UniProt reviewed canonical sequence.

>Q8N8R3|SLC25A29
     1  MALDFLAGCA GGVAGVLVGH PFDTVKVRLQ VQSVEKPQYR GTLHCFKSII KQESVLGLYK
    61  GLGSPLMGLT FINALVFGVQ GNTLRALGHD SPLNQFLAGA AAGAIQCVIC CPMELAKTRL
   121  QLQDAGPART YKGSLDCLAQ IYGHEGLRGV NRGMVSTLLR ETPSFGVYFL TYDALTRALG
   181  CEPGDRLLVP KLLLAGGTSG IVSWLSTYPV DVVKSRLQAD GLRGAPRYRG ILDCVHQSYR
   241  AEGWRVFTRG LASTLLRAFP VNAATFATVT VVLTYARGEE AGPEGEAVPA APAGPALAQP
   301  SSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC25A29 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

6

Mean surface accessibility (rSASA)

0.31

Highest tissue expression

407 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.16

gnomAD pLI

0

gnomAD missense Z

0.77

DepMap mean gene effect

-0.06

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• amino acid transport
• L-arginine transmembrane transport
• L-histidine transmembrane transport
• L-lysine transmembrane transport
• mitochondrial L-ornithine transmembrane transport
• ornithine transport

Molecular functions

• basic amino acid transmembrane transporter activity
• high-affinity L-arginine transmembrane transporter activity
• high-affinity lysine transmembrane transporter activity

Cellular components

• mitochondrial inner membrane
• mitochondrion

Protein domainsUniProt · Pfam · InterPro

• Mitochondrial carrier protein
• Mitochondrial carrier protein, transmembrane region
• Mitochondrial carrier protein domain superfamily
• Mitochondrial Carrier
• Mitochondrial carrier protein

KeywordsUniProt

• Amino-acid transport
• Membrane
• Mitochondrion
• Mitochondrion inner membrane
• Repeat
• Transmembrane
• Transmembrane helix
• Transport