Seroatlas · Human Serome Atlas

SLC25A28

Mitoferrin-2

Also known as: MFRN2_HUMAN, MRS3/4, MRS4L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96A46
Gene: SLC25A28
Ensembl: ENSG00000155287
Chromosome: 10
Canonical length: 364 aa
Protein class: Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to enable ferrous iron transmembrane transporter activity. Predicted to be involved in iron import into the mitochondrion. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

364 residues, UniProt reviewed canonical sequence.

>Q96A46|SLC25A28
     1  MELEGRGAGG VAGGPAAGPG RSPGESALLD GWLQRGVGRG AGGGEAGACR PPVRQDPDSG
    61  PDYEALPAGA TVTTHMVAGA VAGILEHCVM YPIDCVKTRM QSLQPDPAAR YRNVLEALWR
   121  IIRTEGLWRP MRGLNVTATG AGPAHALYFA CYEKLKKTLS DVIHPGGNSH IANGAAGCVA
   181  TLLHDAAMNP AEVVKQRMQM YNSPYHRVTD CVRAVWQNEG AGAFYRSYTT QLTMNVPFQA
   241  IHFMTYEFLQ EHFNPQRRYN PSSHVLSGAC AGAVAAAATT PLDVCKTLLN TQESLALNSH
   301  ITGHITGMAS AFRTVYQVGG VTAYFRGVQA RVIYQIPSTA IAWSVYEFFK YLITKRQEEW
   361  RAGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC25A28 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 96 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 96 nTPM
liver: 94 nTPM
testis: 87 nTPM
urinary bladder: 84 nTPM
midbrain: 83 nTPM
colon: 80 nTPM

Single-cell type

late spermatids: 686 nCPM
late primary spermatocytes: 179 nCPM
early spermatids: 138 nCPM
pdcs: 48 nCPM
bergmann glia: 46 nCPM
adrenal cortex cells: 44 nCPM

Immune cell

plasmacytoid DC: 5.7 nTPM
eosinophil: 3.8 nTPM
gdT-cell: 2.7 nTPM
T-reg: 2.5 nTPM
myeloid DC: 2 nTPM
memory CD4 T-cell: 1.9 nTPM

Brain region

midbrain: 44 nTPM
pons: 35 nTPM
basal ganglia: 34 nTPM
hypothalamus: 34 nTPM
white matter: 31 nTPM
medulla oblongata: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.37
gnomAD pLI: 0.93
gnomAD missense Z: 2.92
DepMap mean gene effect: -0.29
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

iron import into the mitochondrion

Molecular functions

ferrous iron transmembrane transporter activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC25A28 as an antibody target. Whether an autoantibody or antibody against SLC25A28 could matter depends on whether native SLC25A28 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC25A28 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC25A28 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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