SLC25A27

Protein identityUniProt · HPA

UniProt accession

O95847

Gene

SLC25A27

Ensembl

ENSG00000153291

Chromosome

6

Canonical length

323 aa

Protein class

Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters

Subcellular location

Mitochondria

Quaternary structure

Homotetramer

OverviewNCBI Gene

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. Transcripts of this gene are only detected in brain tissue and are specifically modulated by various environmental conditions. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]

Canonical amino-acid sequenceUniProt

323 residues, UniProt reviewed canonical sequence.

>O95847|SLC25A27
     1  MSVPEEEERL LPLTQRWPRA SKFLLSGCAA TVAELATFPL DLTKTRLQMQ GEAALARLGD
    61  GARESAPYRG MVRTALGIIE EEGFLKLWQG VTPAIYRHVV YSGGRMVTYE HLREVVFGKS
   121  EDEHYPLWKS VIGGMMAGVI GQFLANPTDL VKVQMQMEGK RKLEGKPLRF RGVHHAFAKI
   181  LAEGGIRGLW AGWVPNIQRA ALVNMGDLTT YDTVKHYLVL NTPLEDNIMT HGLSSLCSGL
   241  VASILGTPAD VIKSRIMNQP RDKQGRGLLY KSSTDCLIQA VQGEGFMSLY KGFLPSWLRM
   301  TPWSMVFWLT YEKIREMSGV SPF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC25A27 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

6

Mean surface accessibility (rSASA)

0.3

Highest tissue expression

110 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.72

gnomAD pLI

0

gnomAD missense Z

1.34

DepMap mean gene effect

-0.12

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• inner ear development
• intracellular triglyceride homeostasis
• negative regulation of mitochondrial calcium ion concentration
• negative regulation of mitochondrial membrane potential
• negative regulation of neuron apoptotic process
• positive regulation of cell population proliferation
• regulation of D-glucose import
• response to cold

Molecular functions

• chloride transmembrane transporter activity
• protein homodimerization activity
• proton transmembrane transporter activity
• transmembrane transporter activity

Cellular components

• apical part of cell
• mitochondrial inner membrane
• mitochondrial membrane
• mitochondrion
• neuronal cell body

Protein domainsUniProt · Pfam · InterPro

• Mitochondrial carrier protein, transmembrane region
• Mitochondrial carrier protein domain superfamily
• Mitochondrial Metabolite Transporter
• Mitochondrial carrier protein

KeywordsUniProt

• Membrane
• Mitochondrion
• Mitochondrion inner membrane
• Repeat
• Transmembrane
• Transmembrane helix
• Transport