Seroatlas · Human Serome Atlas

SLC25A25

Mitochondrial adenyl nucleotide antiporter SLC25A25

Also known as: KIAA1896, MCSC, PCSCL, SCMC2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6KCM7
Gene: SLC25A25
Ensembl: ENSG00000148339
Chromosome: 9
Canonical length: 469 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Vesicles,Mitochondria

OverviewNCBI Gene

The protein encoded by this gene belongs to the family of calcium-binding mitochondrial carriers, with a characteristic mitochondrial carrier domain at the C-terminus. These proteins are found in the inner membranes of mitochondria, and function as transport proteins. They shuttle metabolites, nucleotides and cofactors through the mitochondrial membrane and thereby connect and/or regulate cytoplasm and matrix functions. This protein may function as an ATP-Mg/Pi carrier that mediates the transport of Mg-ATP in exchange for phosphate, and likely responsible for the net uptake or efflux of adenine nucleotides into or from the mitochondria. Alternatively spliced transcript variants encoding different isoforms with a common C-terminus but variable N-termini have been described for this gene. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

469 residues, UniProt reviewed canonical sequence.

>Q6KCM7|SLC25A25
     1  MLCLCLYVPV IGEAQTEFQY FESKGLPAEL KSIFKLSVFI PSQEFSTYRQ WKQKIVQAGD
    61  KDLDGQLDFE EFVHYLQDHE KKLRLVFKSL DKKNDGRIDA QEIMQSLRDL GVKISEQQAE
   121  KILKSMDKNG TMTIDWNEWR DYHLLHPVEN IPEIILYWKH STIFDVGENL TVPDEFTVEE
   181  RQTGMWWRHL VAGGGAGAVS RTCTAPLDRL KVLMQVHASR SNNMGIVGGF TQMIREGGAR
   241  SLWRGNGINV LKIAPESAIK FMAYEQIKRL VGSDQETLRI HERLVAGSLA GAIAQSSIYP
   301  MEVLKTRMAL RKTGQYSGML DCARRILARE GVAAFYKGYV PNMLGIIPYA GIDLAVYETL
   361  KNAWLQHYAV NSADPGVFVL LACGTMSSTC GQLASYPLAL VRTRMQAQAS IEGAPEVTMS
   421  SLFKHILRTE GAFGLYRGLA PNFMKVIPAV SISYVVYENL KITLGVQSR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC25A25 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 109 nTPM

Expression across tissuesHPA

Tissue

liver: 109 nTPM
pancreas: 72 nTPM
skeletal muscle: 72 nTPM
adipose tissue: 47 nTPM
pituitary gland: 37 nTPM
gallbladder: 35 nTPM

Single-cell type

endometrial luminal cells: 287 nCPM
endometrial glandular cells: 249 nCPM
respiratory ionocytes: 244 nCPM
conjunctival goblet cells: 223 nCPM
esophageal apical cells: 222 nCPM
salivary ionocytes: 221 nCPM

Immune cell

non-classical monocyte: 6.1 nTPM
intermediate monocyte: 5.1 nTPM
naive CD8 T-cell: 4.9 nTPM
memory CD4 T-cell: 3.4 nTPM
total PBMC: 3.2 nTPM
memory CD8 T-cell: 3.1 nTPM

Brain region

medulla oblongata: 36 nTPM
thalamus: 36 nTPM
cerebral cortex: 33 nTPM
midbrain: 32 nTPM
pons: 31 nTPM
hypothalamus: 31 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC25A25.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 59 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Kidney stone

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.58
gnomAD pLI: 0.02
gnomAD missense Z: 1.65
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC25A25 as an antibody target. Whether an autoantibody or antibody against SLC25A25 could matter depends on whether native SLC25A25 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC25A25 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC25A25 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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