Seroatlas · Human Serome Atlas

SLC25A21

Mitochondrial 2-oxodicarboxylate carrier

Also known as: ODC, ODC_HUMAN, ODC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BQT8
Gene
SLC25A21
Ensembl
ENSG00000183032
Chromosome
14
Canonical length
299 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Transporters

OverviewNCBI Gene

SLC25A21 is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria, 2-oxoadipate is converted into acetyl-CoA.[supplied by OMIM, Apr 2004]

Canonical amino-acid sequenceUniProt

299 residues, UniProt reviewed canonical sequence.

>Q9BQT8|SLC25A21
     1  MSAKPEVSLV REASRQIVAG GSAGLVEICL MHPLDVVKTR FQIQRCATDP NSYKSLVDSF
    61  RMIFQMEGLF GFYKGILPPI LAETPKRAVK FFTFEQYKKL LGYVSLSPAL TFAIAGLGSG
   121  LTEAIVVNPF EVVKVGLQAN RNTFAEQPST VGYARQIIKK EGWGLQGLNK GLTATLGRHG
   181  VFNMVYFGFY YNVKNMIPVN KDPILEFWRK FGIGLLSGTI ASVINIPFDV AKSRIQGPQP
   241  VPGEIKYRTC FKTMATVYQE EGILALYKGL LPKIMRLGPG GAVMLLVYEY TYSWLQENW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC25A21 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
5.9 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 5.9 nTPM
  • testis: 3.7 nTPM
  • pancreas: 2.7 nTPM
  • kidney: 1.5 nTPM
  • prostate: 1.5 nTPM
  • salivary gland: 1.5 nTPM

Single-cell type

  • sertoli cells: 1,023 nCPM
  • erythrocyte progenitors: 987 nCPM
  • undifferentiated spermatogonia: 136 nCPM
  • medullary thymic epithelial cells: 113 nCPM
  • myonuclei: 99 nCPM
  • pancreatic acinar cells: 89 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 1.3 nTPM
  • spinal cord: 1.1 nTPM
  • medulla oblongata: 1 nTPM
  • cerebral cortex: 0.9 nTPM
  • hypothalamus: 0.9 nTPM
  • midbrain: 0.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC25A21.

Disease | AllUniProt

Conditions SLC25A21 is implicated in, by any mechanism.

  • Mitochondrial DNA depletion syndrome 18 (MTDPS18) MIM:618811

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 167 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Mitochondrial DNA depletion syndrome 18

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.45
gnomAD pLI
0
gnomAD missense Z
0.02
DepMap mean gene effect
0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC25A21 as an antibody target. Whether an autoantibody or antibody against SLC25A21 could matter depends on whether native SLC25A21 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC25A21 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC25A21 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC25A21. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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