Seroatlas · Human Serome Atlas

SLC25A2

Mitochondrial ornithine transporter 2

Also known as: ORNT2, ORNT2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BXI2
Gene: SLC25A2
Ensembl: ENSG00000120329
Chromosome: 5
Canonical length: 301 aa
Protein class: Metabolic proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This intronless gene encodes a protein that localizes to the mitochondrial inner membrane and likely functions as a transporter of small molecules such as ornithine. This gene is located between the protocadherin beta and gamma gene clusters on chromosome 5. [provided by RefSeq, Dec 2014]

Canonical amino-acid sequenceUniProt

301 residues, UniProt reviewed canonical sequence.

>Q9BXI2|SLC25A2
     1  MKSGPGIQAA IDLTAGAAGG TACVLTGQPF DTIKVKMQTF PDLYKGLTDC FLKTYAQVGL
    61  RGFYKGTGPA LMAYVAENSV LFMCYGFCQQ FVRKVAGMDK QAKLSDLQTA AAGSFASAFA
   121  ALALCPTELV KCRLQTMYEM EMSGKIAKSH NTIWSVVKGI LKKDGPLGFY HGLSSTLLQE
   181  VPGYFFFFGG YELSRSFFAS GRSKDELGPV HLMLSGGVAG ICLWLVVFPV DCIKSRIQVL
   241  SMYGKQAGFI GTLLSVVRNE GIVALYSGLK ATMIRAIPAN GALFVAYEYS RKMMMKQLEA
   301  Y

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC25A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 6.3 nTPM

Expression across tissuesHPA

Tissue

testis: 6.3 nTPM
liver: 0.2 nTPM
pituitary gland: 0.2 nTPM
prostate: 0.2 nTPM
adrenal gland: 0.1 nTPM
breast: 0.1 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 1.3 nTPM
amygdala: 1 nTPM
hippocampal formation: 1 nTPM
basal ganglia: 0.9 nTPM
midbrain: 0.9 nTPM
white matter: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.32
gnomAD pLI: 0
gnomAD missense Z: 0.66
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC25A2 as an antibody target. Whether an autoantibody or antibody against SLC25A2 could matter depends on whether native SLC25A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC25A2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC25A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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