Seroatlas · Human Serome Atlas

SLC25A18

Mitochondrial glutamate carrier 2

Also known as: GHC2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H1K4
Gene: SLC25A18
Ensembl: ENSG00000182902
Chromosome: 22
Canonical length: 315 aa
Protein class: Metabolic proteins, Plasma proteins, Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

Enables amino acid:proton symporter activity. Involved in L-glutamate transmembrane transport. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

315 residues, UniProt reviewed canonical sequence.

>Q9H1K4|SLC25A18
     1  MTHQDLSITA KLINGGVAGL VGVTCVFPID LAKTRLQNQH GKAMYKGMID CLMKTARAEG
    61  FFGMYRGAAV NLTLVTPEKA IKLAANDFFR RLLMEDGMQR NLKMEMLAGC GAGMCQVVVT
   121  CPMEMLKIQL QDAGRLAVHH QGSASAPSTS RSYTTGSAST HRRPSATLIA WELLRTQGLA
   181  GLYRGLGATL LRDIPFSIIY FPLFANLNNL GFNELAGKAS FAHSFVSGCV AGSIAAVAVT
   241  PLDVLKTRIQ TLKKGLGEDM YSGITDCARK LWIQEGPSAF MKGAGCRALV IAPLFGIAQG
   301  VYFIGIGERI LKCFD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC25A18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 139 nTPM

Expression across tissuesHPA

Tissue

amygdala: 139 nTPM
cerebral cortex: 129 nTPM
basal ganglia: 121 nTPM
liver: 107 nTPM
midbrain: 104 nTPM
hippocampal formation: 84 nTPM

Single-cell type

astrocytes: 345 nCPM
hepatocytes: 124 nCPM
bergmann glia: 99 nCPM
podocytes: 47 nCPM
adipocytes: 40 nCPM
prostatic glandular cells: 21 nCPM

Immune cell

eosinophil: 0.3 nTPM
intermediate monocyte: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

thalamus: 137 nTPM
basal ganglia: 109 nTPM
amygdala: 106 nTPM
midbrain: 103 nTPM
hypothalamus: 92 nTPM
cerebral cortex: 90 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.28
gnomAD pLI: 0
gnomAD missense Z: 0.62
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC25A18 as an antibody target. Whether an autoantibody or antibody against SLC25A18 could matter depends on whether native SLC25A18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC25A18 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC25A18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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