Seroatlas · Human Serome Atlas

SLC25A17

Peroxisomal membrane protein PMP34

Also known as: PM34_HUMAN, PMP34

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43808
Gene
SLC25A17
Ensembl
ENSG00000100372
Chromosome
22
Canonical length
307 aa
Protein class
Metabolic proteins, Plasma proteins, Predicted membrane proteins, Transporters
Subcellular location
Peroxisomes

OverviewNCBI Gene

This gene encodes a peroxisomal membrane protein that belongs to the family of mitochondrial solute carriers. It is expressed in the liver, and is likely involved in transport. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Canonical amino-acid sequenceUniProt

307 residues, UniProt reviewed canonical sequence.

>O43808|SLC25A17
     1  MASVLSYESL VHAVAGAVGS VTAMTVFFPL DTARLRLQVD EKRKSKTTHM VLLEIIKEEG
    61  LLAPYRGWFP VISSLCCSNF VYFYTFNSLK ALWVKGQHST TGKDLVVGFV AGVVNVLLTT
   121  PLWVVNTRLK LQGAKFRNED IVPTNYKGII DAFHQIIRDE GISALWNGTF PSLLLVFNPA
   181  IQFMFYEGLK RQLLKKRMKL SSLDVFIIGA VAKAIATTVT YPLQTVQSIL RFGRHRLNPE
   241  NRTLGSLRNI LYLLHQRVRR FGIMGLYKGL EAKLLQTVLT AALMFLVYEK LTAATFTVMG
   301  LKRAHQH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC25A17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
31 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 31 nTPM
  • epididymis: 19 nTPM
  • liver: 16 nTPM
  • endometrium: 14 nTPM
  • breast: 13 nTPM
  • parathyroid gland: 13 nTPM

Single-cell type

  • bergmann glia: 128 nCPM
  • ovarian stromal cells: 122 nCPM
  • myonuclei: 103 nCPM
  • ependymal cells: 95 nCPM
  • leydig cells: 92 nCPM
  • early primary spermatocytes: 90 nCPM

Immune cell

  • T-reg: 8.6 nTPM
  • memory B-cell: 8.4 nTPM
  • naive CD4 T-cell: 8.3 nTPM
  • NK-cell: 8.3 nTPM
  • naive B-cell: 7.6 nTPM
  • basophil: 7.1 nTPM

Brain region

  • choroid plexus: 12 nTPM
  • white matter: 11 nTPM
  • hypothalamus: 8.8 nTPM
  • spinal cord: 8.6 nTPM
  • cerebellum: 8.3 nTPM
  • medulla oblongata: 8.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.96
gnomAD pLI
0
gnomAD missense Z
0.54
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC25A17 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC25A17 as an antibody target. Whether an autoantibody or antibody against SLC25A17 could matter depends on whether native SLC25A17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC25A17 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC25A17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC25A17. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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