Seroatlas · Human Serome Atlas

SLC25A14

Brain mitochondrial carrier protein 1

Also known as: BMCP1, UCP5, UCP5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95258
Gene
SLC25A14
Ensembl
ENSG00000102078
Chromosome
X
Canonical length
325 aa
Protein class
Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Mitochondria
Quaternary structure
Homotetramer

OverviewNCBI Gene

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). Uncoupling proteins separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. Uncoupling proteins facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. This gene is widely expressed in many tissues with the greatest abundance in brain and testis. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on chromosome 4. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

325 residues, UniProt reviewed canonical sequence.

>O95258|SLC25A14
     1  MGIFPGIILI FLRVKFATAA VIVSGHQKST TVSHEMSGLN WKPFVYGGLA SIVAEFGTFP
    61  VDLTKTRLQV QGQSIDARFK EIKYRGMFHA LFRICKEEGV LALYSGIAPA LLRQASYGTI
   121  KIGIYQSLKR LFVERLEDET LLINMICGVV SGVISSTIAN PTDVLKIRMQ AQGSLFQGSM
   181  IGSFIDIYQQ EGTRGLWRGV VPTAQRAAIV VGVELPVYDI TKKHLILSGM MGDTILTHFV
   241  SSFTCGLAGA LASNPVDVVR TRMMNQRAIV GHVDLYKGTV DGILKMWKHE GFFALYKGFW
   301  PNWLRLGPWN IIFFITYEQL KRLQI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC25A14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
16 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 16 nTPM
  • hypothalamus: 16 nTPM
  • cerebral cortex: 15 nTPM
  • choroid plexus: 11 nTPM
  • pituitary gland: 9.9 nTPM
  • retina: 9.4 nTPM

Single-cell type

  • differentiating spermatogonia: 47 nCPM
  • respiratory ciliated cells: 45 nCPM
  • early primary spermatocytes: 38 nCPM
  • somatotrophs: 29 nCPM
  • lactotrophs: 28 nCPM
  • ependymal cells: 28 nCPM

Immune cell

  • T-reg: 4.7 nTPM
  • plasmacytoid DC: 4.5 nTPM
  • neutrophil: 4.1 nTPM
  • memory B-cell: 3.9 nTPM
  • NK-cell: 3.8 nTPM
  • myeloid DC: 3.7 nTPM

Brain region

  • hypothalamus: 24 nTPM
  • cerebral cortex: 18 nTPM
  • basal ganglia: 17 nTPM
  • pons: 14 nTPM
  • hippocampal formation: 14 nTPM
  • thalamus: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.22
gnomAD pLI
0.99
gnomAD missense Z
2.5
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC25A14 as an antibody target. Whether an autoantibody or antibody against SLC25A14 could matter depends on whether native SLC25A14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC25A14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC25A14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC25A14. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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