Seroatlas · Human Serome Atlas

SLC25A10

Mitochondrial dicarboxylate carrier

Also known as: DIC, DIC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UBX3
Gene
SLC25A10
Ensembl
ENSG00000183048
Chromosome
17
Canonical length
287 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Mitochondria

OverviewNCBI Gene

This gene encodes a member of a family of proteins that translocate small metabolites across the mitochondrial membrane. The encoded protein exchanges dicarboxylates, such as malate and succinate, for phosphate, sulfate, and other small molecules, thereby providing substrates for metabolic processes including the Krebs cycle and fatty acid synthesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

Canonical amino-acid sequenceUniProt

287 residues, UniProt reviewed canonical sequence.

>Q9UBX3|SLC25A10
     1  MAAEARVSRW YFGGLASCGA ACCTHPLDLL KVHLQTQQEV KLRMTGMALR VVRTDGILAL
    61  YSGLSASLCR QMTYSLTRFA IYETVRDRVA KGSQGPLPFH EKVLLGSVSG LAGGFVGTPA
   121  DLVNVRMQND VKLPQGQRRN YAHALDGLYR VAREEGLRRL FSGATMASSR GALVTVGQLS
   181  CYDQAKQLVL STGYLSDNIF THFVASFIAG GCATFLCQPL DVLKTRLMNS KGEYQGVFHC
   241  AVETAKLGPL AFYKGLVPAG IRLIPHTVLT FVFLEQLRKN FGIKVPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC25A10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
180 nTPM

Expression across tissuesHPA

Tissue

  • liver: 180 nTPM
  • kidney: 70 nTPM
  • esophagus: 36 nTPM
  • pancreas: 33 nTPM
  • testis: 33 nTPM
  • salivary gland: 25 nTPM

Single-cell type

  • late spermatids: 141 nCPM
  • late primary spermatocytes: 81 nCPM
  • esophageal basal cells: 69 nCPM
  • enteric transient amplifying cells: 58 nCPM
  • esophageal suprabasal cells: 53 nCPM
  • colonocytes: 48 nCPM

Immune cell

  • NK-cell: 1 nTPM
  • memory CD8 T-cell: 0.4 nTPM
  • intermediate monocyte: 0.3 nTPM
  • MAIT T-cell: 0.3 nTPM
  • classical monocyte: 0.2 nTPM
  • naive B-cell: 0.2 nTPM

Brain region

  • medulla oblongata: 11 nTPM
  • white matter: 11 nTPM
  • choroid plexus: 11 nTPM
  • spinal cord: 9.8 nTPM
  • cerebellum: 9.2 nTPM
  • thalamus: 8.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC25A10.

Disease | AllUniProt

Conditions SLC25A10 is implicated in, by any mechanism.

  • Mitochondrial DNA depletion syndrome 19 (MTDPS19) MIM:618972

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 108 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.06
gnomAD pLI
0
gnomAD missense Z
0.55
DepMap mean gene effect
-0.27
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC25A10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC25A10 as an antibody target. Whether an autoantibody or antibody against SLC25A10 could matter depends on whether native SLC25A10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC25A10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC25A10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC25A10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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