Seroatlas · Human Serome Atlas

SLC23A3

Solute carrier family 23 member 3

Also known as: FLJ31168, S23A3_HUMAN, SVCT3, Yspl1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PIS1
Gene: SLC23A3
Ensembl: ENSG00000213901
Chromosome: 2
Canonical length: 610 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Cell Junctions

OverviewNCBI Gene

Predicted to enable transmembrane transporter activity. Involved in hypoxanthine transport. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

610 residues, UniProt reviewed canonical sequence.

>Q6PIS1|SLC23A3
     1  MSRSPLNPSQ LRSVGSQDAL APLPPPAPQN PSTHSWDPLC GSLPWGLSCL LALQHVLVMA
    61  SLLCVSHLLL LCSLSPGGLS YSPSQLLASS FFSCGMSTIL QTWMGSRLPL VQAPSLEFLI
   121  PALVLTSQKL PRAIQTPGNS SLMLHLCRGP SCHGLGHWNT SLQEVSGAVV VSGLLQGMMG
   181  LLGSPGHVFP HCGPLVLAPS LVVAGLSAHR EVAQFCFTHW GLALLVILLM VVCSQHLGSC
   241  QFHVCPWRRA STSSTHTPLP VFRLLSVLIP VACVWIVSAF VGFSVIPQEL SAPTKAPWIW
   301  LPHPGEWNWP LLTPRALAAG ISMALAASTS SLGCYALCGR LLHLPPPPPH ACSRGLSLEG
   361  LGSVLAGLLG SPMGTASSFP NVGKVGLIQA GSQQVAHLVG LLCVGLGLSP RLAQLLTTIP
   421  LPVVGGVLGV TQAVVLSAGF SSFYLADIDS GRNIFIVGFS IFMALLLPRW FREAPVLFST
   481  GWSPLDVLLH SLLTQPIFLA GLSGFLLENT IPGTQLERGL GQGLPSPFTA QEARMPQKPR
   541  EKAAQVYRLP FPIQNLCPCI PQPLHCLCPL PEDPGDEEGG SSEPEEMADL LPGSGEPCPE
   601  SSREGFRSQK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC23A3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 43 nTPM

Expression across tissuesHPA

Tissue

kidney: 43 nTPM
small intestine: 17 nTPM
duodenum: 7.1 nTPM
liver: 3.6 nTPM
colon: 3.2 nTPM
cervix: 2.2 nTPM

Single-cell type

enterocytes: 0.4 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM

Immune cell

memory B-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 1 nTPM
thalamus: 0.8 nTPM
basal ganglia: 0.7 nTPM
choroid plexus: 0.7 nTPM
medulla oblongata: 0.7 nTPM
midbrain: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0
gnomAD missense Z: 1.09
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC23A3 as an antibody target. Whether an autoantibody or antibody against SLC23A3 could matter depends on whether native SLC23A3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC23A3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC23A3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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