Seroatlas · Human Serome Atlas

SLC23A2

Solute carrier family 23 member 2

Also known as: KIAA0238, S23A2_HUMAN, SLC23A1, SVCT2, YSPL2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UGH3
Gene: SLC23A2
Ensembl: ENSG00000089057
Chromosome: 20
Canonical length: 650 aa
Protein class: Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location: Golgi apparatus,Vesicles

OverviewNCBI Gene

The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters and the encoded protein accounts for tissue-specific uptake of vitamin C. Previously, this gene had an official symbol of SLC23A1. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

650 residues, UniProt reviewed canonical sequence.

>Q9UGH3|SLC23A2
     1  MMGIGKNTTS KSMEAGSSTE GKYEDEAKHP AFFTLPVVIN GGATSSGEQD NEDTELMAIY
    61  TTENGIAEKS SLAETLDSTG SLDPQRSDMI YTIEDVPPWY LCIFLGLQHY LTCFSGTIAV
   121  PFLLADAMCV GYDQWATSQL IGTIFFCVGI TTLLQTTFGC RLPLFQASAF AFLAPARAIL
   181  SLDKWKCNTT DVSVANGTAE LLHTEHIWYP RIREIQGAII MSSLIEVVIG LLGLPGALLK
   241  YIGPLTITPT VALIGLSGFQ AAGERAGKHW GIAMLTIFLV LLFSQYARNV KFPLPIYKSK
   301  KGWTAYKLQL FKMFPIILAI LVSWLLCFIF TVTDVFPPDS TKYGFYARTD ARQGVLLVAP
   361  WFKVPYPFQW GLPTVSAAGV IGMLSAVVAS IIESIGDYYA CARLSCAPPP PIHAINRGIF
   421  VEGLSCVLDG IFGTGNGSTS SSPNIGVLGI TKVGSRRVIQ CGAALMLALG MIGKFSALFA
   481  SLPDPVLGAL FCTLFGMITA VGLSNLQFID LNSSRNLFVL GFSIFFGLVL PSYLRQNPLV
   541  TGITGIDQVL NVLLTTAMFV GGCVAFILDN TIPGTPEERG IRKWKKGVGK GNKSLDGMES
   601  YNLPFGMNII KKYRCFSYLP ISPTFVGYTW KGLRKSDNSR SSDEDSQATG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC23A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 99 nTPM

Expression across tissuesHPA

Tissue

retina: 99 nTPM
adrenal gland: 97 nTPM
choroid plexus: 64 nTPM
liver: 54 nTPM
ovary: 36 nTPM
cerebral cortex: 33 nTPM

Single-cell type

retinal bipolar cells: 766 nCPM
retinal pigment epithelial cells: 750 nCPM
choroid plexus epithelial cells: 667 nCPM
adrenal cortex cells: 564 nCPM
cone photoreceptor cells: 547 nCPM
rod photoreceptor cells: 487 nCPM

Immune cell

plasmacytoid DC: 2.4 nTPM
memory B-cell: 1.8 nTPM
myeloid DC: 1.5 nTPM
neutrophil: 1.2 nTPM
classical monocyte: 1.1 nTPM
gdT-cell: 1.1 nTPM

Brain region

choroid plexus: 202 nTPM
thalamus: 87 nTPM
midbrain: 83 nTPM
white matter: 82 nTPM
pons: 75 nTPM
hippocampal formation: 73 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC23A2.

Disease | ImmuneIEDB

Conditions an epitope on SLC23A2 was assayed in.

influenza T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.53
gnomAD pLI: 0.01
gnomAD missense Z: 3.63
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC23A2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CLSTN3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC23A2 as an antibody target. Whether an autoantibody or antibody against SLC23A2 could matter depends on whether native SLC23A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC23A2 is annotated at the cell surface, where native SLC23A2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC23A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...