Seroatlas · Human Serome Atlas

SLC22A17

Solute carrier family 22 member 17

Also known as: BOCT, BOIT, NGALR, S22AH_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WUG5
Gene
SLC22A17
Ensembl
ENSG00000092096
Chromosome
14
Canonical length
649 aa
Protein class
Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in siderophore transport. Located in organelle membrane and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

649 residues, UniProt reviewed canonical sequence.

>Q8WUG5|SLC22A17
     1  MAPRVATGTP EPNGGGGGKI DNTVEITPTS NGQVGTLGDA VPTEQLQGER EREREGEGDA
    61  GGDGLGSSLS LAVPPGPLSF EALLAQVGAL GGGQQLQLGL CCLPVLFVAL GMASDPIFTL
   121  APPLHCHYGA FPPNASGWEQ PPNASGVSVA SAALAASAAS RVATSTDPSC SGFAPPDFNH
   181  CLKDWDYNGL PVLTTNAIGQ WDLVCDLGWQ VILEQILFIL GFASGYLFLG YPADRFGRRG
   241  IVLLTLGLVG PCGVGGAAAG SSTGVMALRF LLGFLLAGVD LGVYLMRLEL CDPTQRLRVA
   301  LAGELVGVGG HFLFLGLALV SKDWRFLQRM ITAPCILFLF YGWPGLFLES ARWLIVKRQI
   361  EEAQSVLRIL AERNRPHGQM LGEEAQEALQ DLENTCPLPA TSSFSFASLL NYRNIWKNLL
   421  ILGFTNFIAH AIRHCYQPVG GGGSPSDFYL CSLLASGTAA LACVFLGVTV DRFGRRGILL
   481  LSMTLTGIAS LVLLGLWDCE HPIFPTVWAQ QGNPNRDLNE AAITTFSVLG LFSSQAAAIL
   541  STLLAAEVIP TTVRGRGLGL IMALGALGGL SGPAQRLHMG HGAFLQHVVL AACALLCILS
   601  IMLLPETKRK LLPEVLRDGE LCRRPSLLRQ PPPTRCDHVP LLATPNPAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC22A17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
11
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
277 nTPM

Expression across tissuesHPA

Tissue

  • hypothalamus: 277 nTPM
  • basal ganglia: 248 nTPM
  • cerebral cortex: 236 nTPM
  • choroid plexus: 235 nTPM
  • cerebellum: 188 nTPM
  • pituitary gland: 178 nTPM

Single-cell type

  • other brain neurons: 280 nCPM
  • pancreatic islet cells: 210 nCPM
  • oligodendrocyte progenitor cells: 178 nCPM
  • brain inhibitory neurons: 171 nCPM
  • prostatic glandular cells: 169 nCPM
  • corticotrophs: 160 nCPM

Immune cell

  • naive CD4 T-cell: 0.7 nTPM
  • memory CD4 T-cell: 0.3 nTPM
  • naive CD8 T-cell: 0.2 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • choroid plexus: 872 nTPM
  • hypothalamus: 732 nTPM
  • basal ganglia: 437 nTPM
  • cerebral cortex: 434 nTPM
  • medulla oblongata: 428 nTPM
  • midbrain: 409 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.58
gnomAD pLI
0.01
gnomAD missense Z
1.42
DepMap mean gene effect
-0.21
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC22A17 as an antibody target. Whether an autoantibody or antibody against SLC22A17 could matter depends on whether native SLC22A17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC22A17 is annotated at the cell surface, where native SLC22A17 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC22A17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC22A17. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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