Seroatlas · Human Serome Atlas

SLC20A2

Sodium-dependent phosphate transporter 2

Also known as: Glvr-2, GLVR2, MLVAR, PiT-2, Ram-1, S20A2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q08357
Gene
SLC20A2
Ensembl
ENSG00000168575
Chromosome
8
Canonical length
652 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the inorganic phosphate transporter family. The encoded protein is a type 3 sodium-dependent phosphate symporter that plays an important role in phosphate homeostasis by mediating cellular phosphate uptake. The encoded protein also confers susceptibility to viral infection as a gamma-retroviral receptor. Mutations in this gene may play a role in familial idiopathic basal ganglia calcification. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

Canonical amino-acid sequenceUniProt

652 residues, UniProt reviewed canonical sequence.

>Q08357|SLC20A2
     1  MAMDEYLWMV ILGFIIAFIL AFSVGANDVA NSFGTAVGSG VVTLRQACIL ASIFETTGSV
    61  LLGAKVGETI RKGIIDVNLY NETVETLMAG EVSAMVGSAV WQLIASFLRL PISGTHCIVG
   121  STIGFSLVAI GTKGVQWMEL VKIVASWFIS PLLSGFMSGL LFVLIRIFIL KKEDPVPNGL
   181  RALPVFYAAT IAINVFSIMY TGAPVLGLVL PMWAIALISF GVALLFAFFV WLFVCPWMRR
   241  KITGKLQKEG ALSRVSDESL SKVQEAESPV FKELPGAKAN DDSTIPLTGA AGETLGTSEG
   301  TSAGSHPRAA YGRALSMTHG SVKSPISNGT FGFDGHTRSD GHVYHTVHKD SGLYKDLLHK
   361  IHIDRGPEEK PAQESNYRLL RRNNSYTCYT AAICGLPVHA TFRAADSSAP EDSEKLVGDT
   421  VSYSKKRLRY DSYSSYCNAV AEAEIEAEEG GVEMKLASEL ADPDQPREDP AEEEKEEKDA
   481  PEVHLLFHFL QVLTACFGSF AHGGNDVSNA IGPLVALWLI YKQGGVTQEA ATPVWLLFYG
   541  GVGICTGLWV WGRRVIQTMG KDLTPITPSS GFTIELASAF TVVIASNIGL PVSTTHCKVG
   601  SVVAVGWIRS RKAVDWRLFR NIFVAWFVTV PVAGLFSAAV MALLMYGILP YV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC20A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
146 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 146 nTPM
  • skeletal muscle: 123 nTPM
  • salivary gland: 83 nTPM
  • thyroid gland: 78 nTPM
  • heart muscle: 59 nTPM
  • tongue: 54 nTPM

Single-cell type

  • myonuclei: 1,453 nCPM
  • choroid plexus epithelial cells: 1,280 nCPM
  • urothelial cells: 883 nCPM
  • endometrial glandular cells: 704 nCPM
  • endometrial ciliated cells: 615 nCPM
  • ocular epithelial cells: 570 nCPM

Immune cell

  • NK-cell: 6.8 nTPM
  • naive CD4 T-cell: 4.8 nTPM
  • MAIT T-cell: 4.3 nTPM
  • T-reg: 4.1 nTPM
  • memory CD4 T-cell: 4 nTPM
  • myeloid DC: 3.7 nTPM

Brain region

  • choroid plexus: 261 nTPM
  • thalamus: 128 nTPM
  • midbrain: 106 nTPM
  • cerebellum: 101 nTPM
  • white matter: 92 nTPM
  • hypothalamus: 87 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC20A2.

Disease | AllUniProt

Conditions SLC20A2 is implicated in, by any mechanism.

  • Basal ganglia calcification, idiopathic, 1 (IBGC1) MIM:213600

Disease | GeneticClinVar

87 pathogenic / likely-pathogenic of 448 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.33
gnomAD pLI
0.97
gnomAD missense Z
2.63
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC20A2 as an antibody target. Whether an autoantibody or antibody against SLC20A2 could matter depends on whether native SLC20A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC20A2 is annotated at the cell surface, where native SLC20A2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC20A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC20A2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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