Seroatlas · Human Serome Atlas

SLC20A1

Sodium-dependent phosphate transporter 1

Also known as: Glvr-1, GLVR1, PiT-1, PiT1, S20A1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WUM9
Gene
SLC20A1
Ensembl
ENSG00000144136
Chromosome
2
Canonical length
679 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene is a sodium-phosphate symporter that absorbs phosphate from interstitial fluid for use in cellular functions such as metabolism, signal transduction, and nucleic acid and lipid synthesis. The encoded protein is also a retroviral receptor, causing human cells to be susceptible to infection by gibbon ape leukemia virus, simian sarcoma-associated virus, feline leukemia virus subgroup B, and 10A1 murine leukemia virus.[provided by RefSeq, Mar 2011]

Canonical amino-acid sequenceUniProt

679 residues, UniProt reviewed canonical sequence.

>Q8WUM9|SLC20A1
     1  MATLITSTTA ATAASGPLVD YLWMLILGFI IAFVLAFSVG ANDVANSFGT AVGSGVVTLK
    61  QACILASIFE TVGSVLLGAK VSETIRKGLI DVEMYNSTQG LLMAGSVSAM FGSAVWQLVA
   121  SFLKLPISGT HCIVGATIGF SLVAKGQEGV KWSELIKIVM SWFVSPLLSG IMSGILFFLV
   181  RAFILHKADP VPNGLRALPV FYACTVGINL FSIMYTGAPL LGFDKLPLWG TILISVGCAV
   241  FCALIVWFFV CPRMKRKIER EIKCSPSESP LMEKKNSLKE DHEETKLSVG DIENKHPVSE
   301  VGPATVPLQA VVEERTVSFK LGDLEEAPER ERLPSVDLKE ETSIDSTVNG AVQLPNGNLV
   361  QFSQAVSNQI NSSGHYQYHT VHKDSGLYKE LLHKLHLAKV GDCMGDSGDK PLRRNNSYTS
   421  YTMAICGMPL DSFRAKEGEQ KGEEMEKLTW PNADSKKRIR MDSYTSYCNA VSDLHSASEI
   481  DMSVKAEMGL GDRKGSNGSL EEWYDQDKPE VSLLFQFLQI LTACFGSFAH GGNDVSNAIG
   541  PLVALYLVYD TGDVSSKVAT PIWLLLYGGV GICVGLWVWG RRVIQTMGKD LTPITPSSGF
   601  SIELASALTV VIASNIGLPI STTHCKVGSV VSVGWLRSKK AVDWRLFRNI FMAWFVTVPI
   661  SGVISAAIMA IFRYVILRM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC20A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
10
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
70 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 70 nTPM
  • colon: 50 nTPM
  • retina: 49 nTPM
  • liver: 46 nTPM
  • urinary bladder: 38 nTPM
  • adipose tissue: 35 nTPM

Single-cell type

  • ocular epithelial cells: 949 nCPM
  • urothelial cells: 798 nCPM
  • epicardial cells: 434 nCPM
  • prostatic hillock cells: 417 nCPM
  • colonocytes: 374 nCPM
  • endometrial glandular cells: 369 nCPM

Immune cell

  • intermediate monocyte: 60 nTPM
  • MAIT T-cell: 60 nTPM
  • gdT-cell: 53 nTPM
  • NK-cell: 50 nTPM
  • plasmacytoid DC: 42 nTPM
  • memory CD8 T-cell: 38 nTPM

Brain region

  • cerebellum: 58 nTPM
  • cerebral cortex: 55 nTPM
  • thalamus: 54 nTPM
  • pons: 53 nTPM
  • choroid plexus: 53 nTPM
  • medulla oblongata: 47 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.48
gnomAD pLI
0.07
gnomAD missense Z
1.85
DepMap mean gene effect
-0.33
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC20A1 as an antibody target. Whether an autoantibody or antibody against SLC20A1 could matter depends on whether native SLC20A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC20A1 is annotated at the cell surface, where native SLC20A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC20A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC20A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...