Seroatlas · Human Serome Atlas

SLC14A2

Urea transporter 2

Also known as: HUT2, UT2, UT2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15849
Gene
SLC14A2
Ensembl
ENSG00000132874
Chromosome
18
Canonical length
920 aa
Protein class
Metabolic proteins, Plasma proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene belongs to the urea transporter family. In mammalian cells, urea is the chief end product of nitrogen catabolism, and plays an important role in the urinary concentration mechanism. This protein is expressed in the inner medulla of the kidney, and mediates rapid transepithelial urea transport across the inner medullary collecting duct. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

920 residues, UniProt reviewed canonical sequence.

>Q15849|SLC14A2
     1  MSDPHSSPLL PEPLSSRYKL YEAEFTSPSW PSTSPDTHPA LPLLEMPEEK DLRSSNEDSH
    61  IVKIEKLNER SKRKDDGVAH RDSAGQRCIC LSKAVGYLTG DMKEYRIWLK DKHLALQFID
   121  WVLRGTAQVM FINNPLSGLI IFIGLLIQNP WWTITGGLGT VVSTLTALAL GQDRSAIASG
   181  LHGYNGMLVG LLMAVFSEKL DYYWWLLFPV TFTAMSCPVL SSALNSIFSK WDLPVFTLPF
   241  NIAVTLYLAA TGHYNLFFPT TLVEPVSSVP NITWTEMEMP LLLQAIPVGV GQVYGCDNPW
   301  TGGVFLVALF ISSPLICLHA AIGSIVGLLA ALSVATPFET IYTGLWSYNC VLSCIAIGGM
   361  FYALTWQTHL LALICALFCA YMEAAISNIM SVVGVPPGTW AFCLATIIFL LLTTNNPAIF
   421  RLPLSKVTYP EANRIYYLTV KSGEEEKAPS GGGGEHPPTA GPKVEEGSEA VLSKHRSVFH
   481  IEWSSIRRRS KVFGKGEHQE RQNKDPFPYR YRKPTVELLD LDTMEESSEI KVETNISKTS
   541  WIRSSMAASG KRVSKALSYI TGEMKECGEG LKDKSPVFQF FDWVLRGTSQ VMFVNNPLSG
   601  ILIILGLFIQ NPWWAISGCL GTIMSTLTAL ILSQDKSAIA AGFHGYNGVL VGLLMAVFSD
   661  KGDYYWWLLL PVIIMSMSCP ILSSALGTIF SKWDLPVFTL PFNITVTLYL AATGHYNLFF
   721  PTTLLQPASA MPNITWSEVQ VPLLLRAIPV GIGQVYGCDN PWTGGIFLIA LFISSPLICL
   781  HAAIGSTMGM LAALTIATPF DSIYFGLCGF NSTLACIAIG GMFYVITWQT HLLAIACALF
   841  AAYLGAALAN MLSVFGLPPC TWPFCLSALT FLLLTTNNPA IYKLPLSKVT YPEANRIYYL
   901  SQERNRRASI ITKYQAYDVS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC14A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
17
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
4.3 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 4.3 nTPM
  • adipose tissue: 1.4 nTPM
  • adrenal gland: 1.2 nTPM
  • small intestine: 1 nTPM
  • parathyroid gland: 0.6 nTPM
  • thyroid gland: 0.6 nTPM

Single-cell type

  • renal collecting duct principal cells: 4,868 nCPM
  • papillary tip epithelial cells: 644 nCPM
  • loop of henle epithelial cells: 333 nCPM
  • renal connecting tubule cells: 254 nCPM
  • renal collecting duct intercalated cells: 238 nCPM
  • oocytes: 78 nCPM

Immune cell

  • eosinophil: 1.5 nTPM
  • basophil: 0.5 nTPM
  • T-reg: 0.3 nTPM
  • memory B-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM
  • neutrophil: 0.1 nTPM

Brain region

  • cerebral cortex: 5.5 nTPM
  • cerebellum: 5 nTPM
  • white matter: 4.9 nTPM
  • basal ganglia: 4.7 nTPM
  • hippocampal formation: 4.6 nTPM
  • hypothalamus: 4.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.98
gnomAD pLI
0
gnomAD missense Z
-0.14
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC14A2 as an antibody target. Whether an autoantibody or antibody against SLC14A2 could matter depends on whether native SLC14A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC14A2 is annotated at the cell surface, where native SLC14A2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC14A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC14A2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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