Seroatlas · Human Serome Atlas

SLC12A9

Solute carrier family 12 member 9

Also known as: CIP1, S12A9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BXP2
Gene: SLC12A9
Ensembl: ENSG00000146828
Chromosome: 7
Canonical length: 914 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to enable potassium:chloride symporter activity. Predicted to be involved in several processes, including chloride ion homeostasis; chloride transmembrane transport; and potassium ion homeostasis. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

914 residues, UniProt reviewed canonical sequence.

>Q9BXP2|SLC12A9
     1  MASESSPLLA YRLLGEEGVA LPANGAGGPG GASARKLSTF LGVVVPTVLS MFSIVVFLRI
    61  GFVVGHAGLL QALAMLLVAY FILALTVLSV CAIATNGAVQ GGGAYFMISR TLGPEVGGSI
   121  GLMFYLANVC GCAVSLLGLV ESVLDVFGAD ATGPSGLRVL PQGYGWNLLY GSLLLGLVGG
   181  VCTLGAGLYA RASFLTFLLV SGSLASVLIS FVAVGPRDIR LTPRPGPNGS SLPPRFGHFT
   241  GFNSSTLKDN LGAGYAEDYT TGAVMNFASV FAVLFNGCTG IMAGANMSGE LKDPSRAIPL
   301  GTIVAVAYTF FVYVLLFFLS SFTCDRTLLQ EDYGFFRAIS LWPPLVLIGI YATALSASMS
   361  SLIGASRILH ALARDDLFGV ILAPAKVVSR GGNPWAAVLY SWGLVQLVLL AGKLNTLAAV
   421  VTVFYLVAYA AVDLSCLSLE WASAPNFRPT FSLFSWHTCL LGVASCLLMM FLISPGAAGG
   481  SLLLMGLLAA LLTARGGPSS WGYVSQALLF HQVRKYLLRL DVRKDHVKFW RPQLLLLVGN
   541  PRGALPLLRL ANQLKKGGLY VLGHVTLGDL DSLPSDPVQP QYGAWLSLVD RAQVKAFVDL
   601  TLSPSVRQGA QHLLRISGLG GMKPNTLVLG FYDDAPPQDH FLTDPAFSEP ADSTREGSSP
   661  ALSTLFPPPR APGSPRALNP QDYVATVADA LKMNKNVVLA RASGALPPER LSRGSGGTSQ
   721  LHHVDVWPLN LLRPRGGPGY VDVCGLFLLQ MATILGMVPA WHSARLRIFL CLGPREAPGA
   781  AEGRLRALLS QLRIRAEVQE VVWGEGAGAG EPEAEEEGDF VNSGRGDAEA EALARSANAL
   841  VRAQQGRGTG GGPGGPEGGD AEGPITALTF LYLPRPPADP ARYPRYLALL ETLTRDLGPT
   901  LLVHGVTPVT CTDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC12A9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 14 nTPM
spleen: 14 nTPM
placenta: 13 nTPM
pancreas: 9.9 nTPM
midbrain: 9.8 nTPM
gallbladder: 9 nTPM

Single-cell type

cytotrophoblasts: 124 nCPM
neutrophils: 95 nCPM
migrating cytotrophoblasts: 76 nCPM
syncytiotrophoblasts: 56 nCPM
cdc: 49 nCPM
tuft cells: 46 nCPM

Immune cell

myeloid DC: 2.4 nTPM
non-classical monocyte: 2 nTPM
intermediate monocyte: 1.9 nTPM
classical monocyte: 1.5 nTPM
neutrophil: 1.5 nTPM
plasmacytoid DC: 1.2 nTPM

Brain region

white matter: 21 nTPM
medulla oblongata: 21 nTPM
basal ganglia: 17 nTPM
cerebellum: 17 nTPM
midbrain: 16 nTPM
cerebral cortex: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.16
gnomAD pLI: 0
gnomAD missense Z: 2.44
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC12A9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SLC12A1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC12A9 as an antibody target. Whether an autoantibody or antibody against SLC12A9 could matter depends on whether native SLC12A9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC12A9 is annotated at the cell surface, where native SLC12A9 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC12A9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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