Seroatlas · Human Serome Atlas

SLC12A8

Solute carrier family 12 member 8

Also known as: CCC9, S12A8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0AV02
Gene
SLC12A8
Ensembl
ENSG00000221955
Chromosome
3
Canonical length
714 aa
Protein class
Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene is thought to be a candidate for psoriasis susceptibility. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Sep 2010]

Canonical amino-acid sequenceUniProt

714 residues, UniProt reviewed canonical sequence.

>A0AV02|SLC12A8
     1  MTQMSQVQEL FHEAAQQDAL AQPQPWWKTQ LFMWEPVLFG TWDGVFTSCM INIFGVVLFL
    61  RTGWLVGNTG VLLGMFLVSF VILVALVTVL SGIGVGERSS IGSGGVYSMI SSVLGGQTGG
   121  TIGLLYVFGQ CVAGAMYITG FAESISDLLG LGNIWAVRGI SVAVLLALLG INLAGVKWII
   181  RLQLLLLFLL AVSTLDFVVG SFTHLDPEHG FIGYSPELLQ NNTLPDYSPG ESFFTVFGVF
   241  FPAATGVMAG FNMGGDLREP AASIPLGSLA AVGISWFLYI IFVFLLGAIC TREALRYDFL
   301  IAEKVSLMGF LFLLGLYISS LASCMGGLYG APRILQCIAQ EKVIPALACL GQGKGPNKTP
   361  VAAICLTSLV TMAFVFVGQV NVLAPIVTIN FMLTYVAVDY SYFSLSMCSC SLTPVPEPVL
   421  REGAEGLHCS EHLLLEKAPS YGSEGPAQRV LEGTLLEFTK DMDQLLQLTR KLESSQPRQG
   481  EGNRTPESQK RKSKKATKQT LQDSFLLDLK SPPSFPVEIS DRLPAASWEG QESCWNKQTS
   541  KSEGTQPEGT YGEQLVPELC NQSESSGEDF FLKSRLQEQD VWRRSTSFYT HMCNPWVSLL
   601  GAVGSLLIMF VIQWVYTLVN MGVAAIVYFY IGRASPGLHL GSASNFSFFR WMRSLLLPSC
   661  RSLRSPQEQI ILAPSLAKVD MEMTQLTQEN ADFATRDRYH HSSLVNREQL MPHY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC12A8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
13
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 21 nTPM
  • choroid plexus: 13 nTPM
  • salivary gland: 11 nTPM
  • pancreas: 9.2 nTPM
  • gallbladder: 7.7 nTPM
  • liver: 6 nTPM

Single-cell type

  • goblet cells: 157 nCPM
  • choroid plexus epithelial cells: 155 nCPM
  • salivary acinar cells: 83 nCPM
  • lacrimal acinar cells: 76 nCPM
  • alveolar cells type 1: 75 nCPM
  • gonadotrophs: 61 nCPM

Immune cell

  • basophil: 0.2 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 26 nTPM
  • hippocampal formation: 7.9 nTPM
  • basal ganglia: 7.3 nTPM
  • cerebral cortex: 7.2 nTPM
  • amygdala: 6.6 nTPM
  • hypothalamus: 5.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.23
gnomAD pLI
0
gnomAD missense Z
-0.31
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC12A8 as an antibody target. Whether an autoantibody or antibody against SLC12A8 could matter depends on whether native SLC12A8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC12A8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC12A8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC12A8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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