Seroatlas · Human Serome Atlas

SLC11A1

Natural resistance-associated macrophage protein 1

Also known as: LSH, NRAM1_HUMAN, NRAMP, NRAMP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P49279
Gene
SLC11A1
Ensembl
ENSG00000018280
Chromosome
2
Canonical length
550 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location
Nucleoli,Mitochondria

OverviewNCBI Gene

This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

550 residues, UniProt reviewed canonical sequence.

>P49279|SLC11A1
     1  MTGDKGPQRL SGSSYGSISS PTSPTSPGPQ QAPPRETYLS EKIPIPDTKP GTFSLRKLWA
    61  FTGPGFLMSI AFLDPGNIES DLQAGAVAGF KLLWVLLWAT VLGLLCQRLA ARLGVVTGKD
   121  LGEVCHLYYP KVPRTVLWLT IELAIVGSDM QEVIGTAIAF NLLSAGRIPL WGGVLITIVD
   181  TFFFLFLDNY GLRKLEAFFG LLITIMALTF GYEYVVARPE QGALLRGLFL PSCPGCGHPE
   241  LLQAVGIVGA IIMPHNIYLH SALVKSREID RARRADIREA NMYFLIEATI ALSVSFIINL
   301  FVMAVFGQAF YQKTNQAAFN ICANSSLHDY AKIFPMNNAT VAVDIYQGGV ILGCLFGPAA
   361  LYIWAIGLLA AGQSSTMTGT YAGQFVMEGF LRLRWSRFAR VLLTRSCAIL PTVLVAVFRD
   421  LRDLSGLNDL LNVLQSLLLP FAVLPILTFT SMPTLMQEFA NGLLNKVVTS SIMVLVCAIN
   481  LYFVVSYLPS LPHPAYFGLA ALLAAAYLGL STYLVWTCCL AHGATFLAHS SHHHFLYGLL
   541  EEDQKGETSG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC11A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
84 nTPM

Expression across tissuesHPA

Tissue

  • lung: 84 nTPM
  • spleen: 52 nTPM
  • choroid plexus: 34 nTPM
  • adipose tissue: 15 nTPM
  • spinal cord: 12 nTPM
  • blood vessel: 9.8 nTPM

Single-cell type

  • neutrophils: 2,204 nCPM
  • monocytes: 689 nCPM
  • macrophages: 225 nCPM
  • neutrophil progenitors: 104 nCPM
  • kupffer cells: 80 nCPM
  • hofbauer cells: 60 nCPM

Immune cell

  • classical monocyte: 6.1 nTPM
  • non-classical monocyte: 6.1 nTPM
  • intermediate monocyte: 4.5 nTPM
  • neutrophil: 4.4 nTPM
  • total PBMC: 2 nTPM
  • myeloid DC: 1.9 nTPM

Brain region

  • thalamus: 31 nTPM
  • cerebral cortex: 11 nTPM
  • medulla oblongata: 10 nTPM
  • white matter: 10 nTPM
  • pons: 9.2 nTPM
  • spinal cord: 6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.35
gnomAD pLI
0
gnomAD missense Z
0.5
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC11A1 as an antibody target. Whether an autoantibody or antibody against SLC11A1 could matter depends on whether native SLC11A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC11A1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC11A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC11A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...