Seroatlas · Human Serome Atlas

SLAMF8

SLAM family member 8

Also known as: BLAME, CD353, SBBI42, SLAF8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P0V8
Gene
SLAMF8
Ensembl
ENSG00000158714
Chromosome
1
Canonical length
285 aa
Protein class
CD markers, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the CD2 family of cell surface proteins involved in lymphocyte activation. These proteins are characterized by Ig domains. This protein is expressed in lymphoid tissues, and studies of a similar protein in mouse suggest that it may function during B cell lineage commitment. The gene is found in a region of chromosome 1 containing many CD2 genes. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

285 residues, UniProt reviewed canonical sequence.

>Q9P0V8|SLAMF8
     1  MVMRPLWSLL LWEALLPITV TGAQVLSKVG GSVLLVAARP PGFQVREAIW RSLWPSEELL
    61  ATFFRGSLET LYHSRFLGRA QLHSNLSLEL GPLESGDSGN FSVLMVDTRG QPWTQTLQLK
   121  VYDAVPRPVV QVFIAVERDA QPSKTCQVFL SCWAPNISEI TYSWRRETTM DFGMEPHSLF
   181  TDGQVLSISL GPGDRDVAYS CIVSNPVSWD LATVTPWDSC HHEAAPGKAS YKDVLLVVVP
   241  VSLLLMLVTL FSAWHWCPCS GKKKKDVHAD RVGPETENPL VQDLP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLAMF8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
31 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 31 nTPM
  • appendix: 28 nTPM
  • tonsil: 17 nTPM
  • lung: 15 nTPM
  • spleen: 11 nTPM
  • thymus: 9.8 nTPM

Single-cell type

  • cdc: 66 nCPM
  • macrophages: 38 nCPM
  • cardiomyocytes: 18 nCPM
  • kupffer cells: 13 nCPM
  • monocytes: 13 nCPM
  • hofbauer cells: 12 nCPM

Immune cell

  • myeloid DC: 14 nTPM
  • NK-cell: 8.9 nTPM
  • intermediate monocyte: 8 nTPM
  • classical monocyte: 5.8 nTPM
  • memory CD8 T-cell: 4.6 nTPM
  • gdT-cell: 3.5 nTPM

Brain region

  • thalamus: 14 nTPM
  • pons: 7.5 nTPM
  • medulla oblongata: 6.7 nTPM
  • white matter: 6.6 nTPM
  • choroid plexus: 3.7 nTPM
  • spinal cord: 2.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.19
gnomAD pLI
0
gnomAD missense Z
-0.29
DepMap mean gene effect
-0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLAMF8 as an antibody target. Whether an autoantibody or antibody against SLAMF8 could matter depends on whether native SLAMF8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLAMF8 is annotated at the cell surface, where native SLAMF8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLAMF8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLAMF8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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