Seroatlas · Human Serome Atlas

SLAMF6

SLAM family member 6

Also known as: CD352, KALI, KALIb, Ly108, NTB-A, NTBA, SF2000, SLAF6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96DU3
Gene
SLAMF6
Ensembl
ENSG00000162739
Chromosome
1
Canonical length
332 aa
Protein class
CD markers, Predicted membrane proteins
Subcellular location
Plasma membrane,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

332 residues, UniProt reviewed canonical sequence.

>Q96DU3|SLAMF6
     1  MLWLFQSLLF VFCFGPGNVV SQSSLTPLMV NGILGESVTL PLEFPAGEKV NFITWLFNET
    61  SLAFIVPHET KSPEIHVTNP KQGKRLNFTQ SYSLQLSNLK MEDTGSYRAQ ISTKTSAKLS
   121  SYTLRILRQL RNIQVTNHSQ LFQNMTCELH LTCSVEDADD NVSFRWEALG NTLSSQPNLT
   181  VSWDPRISSE QDYTCIAENA VSNLSFSVSA QKLCEDVKIQ YTDTKMILFM VSGICIVFGF
   241  IILLLLVLRK RRDSLSLSTQ RTQGPAESAR NLEYVSVSPT NNTVYASVTH SNRETEIWTP
   301  RENDTITIYS TINHSKESKP TFSRATALDN VV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLAMF6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
58 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 58 nTPM
  • tonsil: 46 nTPM
  • spleen: 31 nTPM
  • appendix: 20 nTPM
  • thymus: 18 nTPM
  • small intestine: 13 nTPM

Single-cell type

  • t-cells: 136 nCPM
  • nk-cells: 110 nCPM
  • b-cells: 63 nCPM
  • innate lymphoid cells: 38 nCPM
  • late spermatids: 29 nCPM
  • plasma cells: 20 nCPM

Immune cell

  • memory CD8 T-cell: 71 nTPM
  • gdT-cell: 56 nTPM
  • T-reg: 46 nTPM
  • NK-cell: 42 nTPM
  • naive CD8 T-cell: 40 nTPM
  • MAIT T-cell: 39 nTPM

Brain region

  • cerebellum: 3.6 nTPM
  • cerebral cortex: 2.7 nTPM
  • medulla oblongata: 2.7 nTPM
  • thalamus: 2.7 nTPM
  • choroid plexus: 2.6 nTPM
  • pons: 2.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.68
gnomAD pLI
0.02
gnomAD missense Z
0.57
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLAMF6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

  • PTN6

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLAMF6 as an antibody target. Whether an autoantibody or antibody against SLAMF6 could matter depends on whether native SLAMF6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLAMF6 is annotated at the cell surface, where native SLAMF6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLAMF6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLAMF6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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