Seroatlas · Human Serome Atlas

SIRPB2

Signal-regulatory protein beta-2

Also known as: dJ776F14.2, PTPN1L, PTPNS1L3, SIRB2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5JXA9
Gene: SIRPB2
Ensembl: ENSG00000196209
Chromosome: 20
Canonical length: 342 aa
Protein class: Predicted membrane proteins
Subcellular location: Nuclear bodies

OverviewNCBI Gene

Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

342 residues, UniProt reviewed canonical sequence.

>Q5JXA9|SIRPB2
     1  MCSTMSAPTC LAHLPPCFLL LALVLVPSDA SGQSSRNDWQ VLQPEGPMLV AEGETLLLRC
    61  MVVGSCTDGM IKWVKVSTQD QQEIYNFKRG SFPGVMPMIQ RTSEPLNCDY SIYIHNVTRE
   121  HTGTYHCVRF DGLSEHSEMK SDEGTSVLVK GAGDPEPDLW IIQPQELVLG TTGDTVFLNC
   181  TVLGDGPPGP IRWFQGAGLS REAIYNFGGI SHPKETAVQA SNNDFSILLQ NVSSEDAGTY
   241  YCVKFQRKPN RQYLSGQGTS LKVKAKSTSS KEAEFTSEPA TEMSPTGLLV VFAPVVLGLK
   301  AITLAALLLA LATSRRSPGQ EDVKTTGPAG AMNTLAWSKG QE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SIRPB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

spleen: 12 nTPM
appendix: 11 nTPM
placenta: 7 nTPM
lung: 6.8 nTPM
lymph node: 6.5 nTPM
bone marrow: 6.1 nTPM

Single-cell type

neutrophils: 280 nCPM
monocyte progenitors: 98 nCPM
monocytes: 95 nCPM
kupffer cells: 94 nCPM
neutrophil progenitors: 86 nCPM
macrophages: 57 nCPM

Immune cell

neutrophil: 70 nTPM
classical monocyte: 51 nTPM
eosinophil: 32 nTPM
intermediate monocyte: 30 nTPM
non-classical monocyte: 25 nTPM
myeloid DC: 21 nTPM

Brain region

medulla oblongata: 5.9 nTPM
thalamus: 5.9 nTPM
white matter: 5.8 nTPM
pons: 5.6 nTPM
cerebral cortex: 4.4 nTPM
choroid plexus: 4.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0
gnomAD missense Z: 0.21
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SIRPB2 as an antibody target. Whether an autoantibody or antibody against SIRPB2 could matter depends on whether native SIRPB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SIRPB2 is annotated at the cell surface, where native SIRPB2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SIRPB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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