Seroatlas · Human Serome Atlas

SIGLEC8

Sialic acid-binding Ig-like lectin 8

Also known as: MGC59785, SAF2, SIGL8_HUMAN, SIGLEC-8, SIGLEC8L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NYZ4
Gene
SIGLEC8
Ensembl
ENSG00000105366
Chromosome
19
Canonical length
499 aa
Protein class
CD markers, Plasma proteins, Predicted membrane proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).[supplied by OMIM, May 2010]

Canonical amino-acid sequenceUniProt

499 residues, UniProt reviewed canonical sequence.

>Q9NYZ4|SIGLEC8
     1  MLLLLLLLPL LWGTKGMEGD RQYGDGYLLQ VQELVTVQEG LCVHVPCSFS YPQDGWTDSD
    61  PVHGYWFRAG DRPYQDAPVA TNNPDREVQA ETQGRFQLLG DIWSNDCSLS IRDARKRDKG
   121  SYFFRLERGS MKWSYKSQLN YKTKQLSVFV TALTHRPDIL ILGTLESGHS RNLTCSVPWA
   181  CKQGTPPMIS WIGASVSSPG PTTARSSVLT LTPKPQDHGT SLTCQVTLPG TGVTTTSTVR
   241  LDVSYPPWNL TMTVFQGDAT ASTALGNGSS LSVLEGQSLR LVCAVNSNPP ARLSWTRGSL
   301  TLCPSRSSNP GLLELPRVHV RDEGEFTCRA QNAQGSQHIS LSLSLQNEGT GTSRPVSQVT
   361  LAAVGGAGAT ALAFLSFCII FIIVRSCRKK SARPAAGVGD TGMEDAKAIR GSASQGPLTE
   421  SWKDGNPLKK PPPAVAPSSG EEGELHYATL SFHKVKPQDP QGQEATDSEY SEIKIHKRET
   481  AETQACLRNH NPSSKEVRG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SIGLEC8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
8.8 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 8.8 nTPM
  • lymph node: 6.4 nTPM
  • spleen: 6.1 nTPM
  • midbrain: 5.1 nTPM
  • adrenal gland: 3.7 nTPM
  • cerebral cortex: 3.7 nTPM

Single-cell type

  • microglia: 57 nCPM
  • kupffer cells: 39 nCPM
  • mast cells: 32 nCPM
  • macrophages: 12 nCPM
  • adrenal cortex cells: 1.3 nCPM
  • salivary myoepithelial cells: 0.6 nCPM

Immune cell

  • eosinophil: 291 nTPM
  • basophil: 7.6 nTPM
  • neutrophil: 2.5 nTPM
  • classical monocyte: 0.4 nTPM
  • non-classical monocyte: 0.4 nTPM
  • intermediate monocyte: 0.3 nTPM

Brain region

  • white matter: 36 nTPM
  • medulla oblongata: 32 nTPM
  • thalamus: 29 nTPM
  • pons: 23 nTPM
  • spinal cord: 20 nTPM
  • midbrain: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.06
gnomAD pLI
0
gnomAD missense Z
0.08
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SIGLEC8 as an antibody target. Whether an autoantibody or antibody against SIGLEC8 could matter depends on whether native SIGLEC8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SIGLEC8 is annotated at the cell surface, where native SIGLEC8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SIGLEC8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SIGLEC8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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