Seroatlas · Human Serome Atlas

SIGLEC16

Sialic acid-binding Ig-like lectin 16

Also known as: SIG16_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NMB1
Gene: SIGLEC16
Canonical length: 481 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for SIGLEC16 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

481 residues, UniProt reviewed canonical sequence.

>A6NMB1|SIGLEC16
     1  MLLLPLLLPV LGAGSLNKDP SYSLQVQRQV PVPEGLCVIV SCNLSYPRDG WDESTAAYGY
    61  WFKGRTSPKT GAPVATNNQS REVAMSTRDR FQLTGDPGKG SCSLVIRDAQ REDEAWYFFR
   121  VERGSRVRHS FLSNAFFLKV TALTQKPDVY IPETLEPGQP VTVICVFNWA FKKCPAPSFS
   181  WTGAALSPRR TRPSTSHFSV LSFTPSPQDH DTDLTCHVDF SRKGVSAQRT VRLRVASLEL
   241  QGNVIYLEVQ KGQFLRLLCA ADSQPPATLS WVLQDRVLSS SHPWGPRTLG LELPGVKAGD
   301  SGRYTCRAEN RLGSQQRALD LSVQYPPENL RVMVSQANRT VLENLRNGTS LRVLEGQSLR
   361  LVCVTHSSPP ARLSWTWGEQ TVGPSQPSDP GVLQLPRVQM EHEGEFTCHA RHPLGSQRVS
   421  LSFSVHCKSG PMTGVVLVAV GEVAMKILLL CLCLILLRVR SCRRKAARAA LGMEAADAVT
   481  D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SIGLEC16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

ovary: 22 nTPM
spleen: 6.1 nTPM
appendix: 1.9 nTPM
lung: 1.4 nTPM
liver: 0.9 nTPM
smooth muscle: 0.9 nTPM

Single-cell type

kupffer cells: 25 nCPM
late spermatids: 19 nCPM
ovarian stromal cells: 15 nCPM
monocytes: 11 nCPM
macrophages: 7.7 nCPM
microglia: 4.7 nCPM

Immune cell

non-classical monocyte: 2.9 nTPM
eosinophil: 1.3 nTPM
intermediate monocyte: 1.1 nTPM
neutrophil: 0.7 nTPM
basophil: 0.3 nTPM
classical monocyte: 0.3 nTPM

Brain region

thalamus: 4.7 nTPM
white matter: 4.4 nTPM
choroid plexus: 4.3 nTPM
medulla oblongata: 4.2 nTPM
cerebral cortex: 4.1 nTPM
basal ganglia: 4 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SIGLEC16 as an antibody target. Whether an autoantibody or antibody against SIGLEC16 could matter depends on whether native SIGLEC16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SIGLEC16 is annotated at the cell surface, where native SIGLEC16 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SIGLEC16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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