Seroatlas · Human Serome Atlas

SIGLEC11

Sialic acid-binding Ig-like lectin 11

Also known as: SIG11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96RL6
Gene: SIGLEC11
Ensembl: ENSG00000161640
Chromosome: 19
Canonical length: 698 aa
Protein class: Plasma proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. This family member mediates anti-inflammatory and immunosuppressive signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

698 residues, UniProt reviewed canonical sequence.

>Q96RL6|SIGLEC11
     1  MVPGQAQPQS PEMLLLPLLL PVLGAGSLNK DPSYSLQVQR QVPVPEGLCV IVSCNLSYPR
    61  DGWDESTAAY GYWFKGRTSP KTGAPVATNN QSREVEMSTR DRFQLTGDPG KGSCSLVIRD
   121  AQREDEAWYF FRVERGSRVR HSFLSNAFFL KVTALTKKPD VYIPETLEPG QPVTVICVFN
   181  WAFKKCPAPS FSWTGAALSP RRTRPSTSHF SVLSFTPSPQ DHDTDLTCHV DFSRKGVSAQ
   241  RTVRLRVAYA PKDLIISISH DNTSALELQG NVIYLEVQKG QFLRLLCAAD SQPPATLSWV
   301  LQDRVLSSSH PWGPRTLGLE LRGVRAGDSG RYTCRAENRL GSQQQALDLS VQYPPENLRV
   361  MVSQANRTVL ENLGNGTSLP VLEGQSLRLV CVTHSSPPAR LSWTRWGQTV GPSQPSDPGV
   421  LELPPIQMEH EGEFTCHAQH PLGSQHVSLS LSVHYPPQLL GPSCSWEAEG LHCSCSSQAS
   481  PAPSLRWWLG EELLEGNSSQ GSFEVTPSSA GPWANSSLSL HGGLSSGLRL RCKAWNVHGA
   541  QSGSVFQLLP GKLEHGGGLG LGAALGAGVA ALLAFCSCLV VFRVKICRKE ARKRAAAEQD
   601  VPSTLGPISQ GHQHECSAGS SQDHPPPGAA TYTPGKGEEQ ELHYASLSFQ GLRLWEPADQ
   661  EAPSTTEYSE IKIHTGQPLR GPGFGLQLER EMSGMVPK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SIGLEC11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 53 nTPM

Expression across tissuesHPA

Tissue

ovary: 53 nTPM
spleen: 22 nTPM
adrenal gland: 7 nTPM
stomach: 4.3 nTPM
pancreas: 2.5 nTPM
appendix: 1.7 nTPM

Single-cell type

microglia: 30 nCPM
parietal cells: 5.3 nCPM
ovarian stromal cells: 2.6 nCPM
macrophages: 2.4 nCPM
kupffer cells: 1 nCPM
neuroendocrine cells: 0.5 nCPM

Immune cell

eosinophil: 1.4 nTPM
non-classical monocyte: 1.3 nTPM
intermediate monocyte: 1.1 nTPM
classical monocyte: 0.3 nTPM
neutrophil: 0.3 nTPM
myeloid DC: 0.2 nTPM

Brain region

thalamus: 5 nTPM
white matter: 4.5 nTPM
medulla oblongata: 4.4 nTPM
pons: 4.1 nTPM
midbrain: 3.8 nTPM
cerebral cortex: 3.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.56
gnomAD pLI: 0
gnomAD missense Z: -0.95
DepMap mean gene effect: -0.36
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell adhesion

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SIGLEC11 as an antibody target. Whether an autoantibody or antibody against SIGLEC11 could matter depends on whether native SIGLEC11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SIGLEC11 is annotated at the cell surface, where native SIGLEC11 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SIGLEC11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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