Seroatlas · Human Serome Atlas

SIDT1

SID1 transmembrane family member 1

Also known as: FLJ20174, SID-1, SIDT1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NXL6
Gene: SIDT1
Ensembl: ENSG00000072858
Chromosome: 3
Canonical length: 827 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene belongs to SID1 family of transmembrane dsRNA-gated channels. Family members transport dsRNA into cells and are required for systemic RNA interference. [provided by RefSeq, May 2017]

Canonical amino-acid sequenceUniProt

827 residues, UniProt reviewed canonical sequence.

>Q9NXL6|SIDT1
     1  MRGCLRLALL CALPWLLLAA SPGHPAKSPR QPPAPRRDPF DAARGADFDH VYSGVVNLST
    61  ENIYSFNYTS QPDQVTAVRV YVNSSSENLN YPVLVVVRQQ KEVLSWQVPL LFQGLYQRSY
   121  NYQEVSRTLC PSEATNETGP LQQLIFVDVA SMAPLGAQYK LLVTKLKHFQ LRTNVAFHFT
   181  ASPSQPQYFL YKFPKDVDSV IIKVVSEMAY PCSVVSVQNI MCPVYDLDHN VEFNGVYQSM
   241  TKKAAITLQK KDFPGEQFFV VFVIKPEDYA CGGSFFIQEK ENQTWNLQRK KNLEVTIVPS
   301  IKESVYVKSS LFSVFIFLSF YLGCLLVGFV HYLRFQRKSI DGSFGSNDGS GNMVASHPIA
   361  ASTPEGSNYG TIDESSSSPG RQMSSSDGGP PGQSDTDSSV EESDFDTMPD IESDKNIIRT
   421  KMFLYLSDLS RKDRRIVSKK YKIYFWNIIT IAVFYALPVI QLVITYQTVV NVTGNQDICY
   481  YNFLCAHPLG VLSAFNNILS NLGHVLLGFL FLLIVLRRDI LHRRALEAKD IFAVEYGIPK
   541  HFGLFYAMGI ALMMEGVLSA CYHVCPNYSN FQFDTSFMYM IAGLCMLKLY QTRHPDINAS
   601  AYSAYASFAV VIMVTVLGVV FGKNDVWFWV IFSAIHVLAS LALSTQIYYM GRFKIDLGIF
   661  RRAAMVFYTD CIQQCSRPLY MDRMVLLVVG NLVNWSFALF GLIYRPRDFA SYMLGIFICN
   721  LLLYLAFYII MKLRSSEKVL PVPLFCIVAT AVMWAAALYF FFQNLSSWEG TPAESREKNR
   781  ECILLDFFDD HDIWHFLSAT ALFFSFLVLL TLDDDLDVVR RDQIPVF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SIDT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 11
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 11 nTPM
salivary gland: 10 nTPM
rectum: 9.6 nTPM
tonsil: 8.3 nTPM
lymph node: 8.2 nTPM
cerebral cortex: 7.1 nTPM

Single-cell type

goblet cells: 217 nCPM
thyrotrophs: 210 nCPM
nk-cells: 190 nCPM
b-cells: 179 nCPM
neuroendocrine cells: 148 nCPM
thymocytes: 139 nCPM

Immune cell

plasmacytoid DC: 34 nTPM
NK-cell: 9.2 nTPM
memory B-cell: 7.5 nTPM
gdT-cell: 7.1 nTPM
MAIT T-cell: 7.1 nTPM
naive B-cell: 6.7 nTPM

Brain region

cerebral cortex: 21 nTPM
spinal cord: 21 nTPM
basal ganglia: 18 nTPM
hypothalamus: 18 nTPM
cerebellum: 17 nTPM
thalamus: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0
gnomAD missense Z: -0.11
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

RNA transport

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SIDT1 as an antibody target. Whether an autoantibody or antibody against SIDT1 could matter depends on whether native SIDT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SIDT1 is annotated at the cell surface, where native SIDT1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SIDT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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