Seroatlas · Human Serome Atlas

SHROOM1

Protein Shroom1

Also known as: APXL2, KIAA1960, SHRM1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q2M3G4
Gene
SHROOM1
Ensembl
ENSG00000164403
Chromosome
5
Canonical length
852 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles

OverviewNCBI Gene

SHROOM family members play diverse roles in the development of the nervous system and other tissues (Hagens et al., 2006 [PubMed 16615870]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

852 residues, UniProt reviewed canonical sequence.

>Q2M3G4|SHROOM1
     1  MEALGPGGDR ASPASSTSSL DLWHLSMRAD SAYSSFSAAS GGPEPRTQSP GTDLLPYLDW
    61  DYVRVVWGGP GPAPPDAALC TSPRPRPAVA ARSGPQPTEV PGTPGPLNRQ ATPLLYALAA
   121  EAEAAAQAAE PPSPPASRAA YRQRLQGAQR RVLRETSFQR KELRMSLPAR LRPTVPARPP
   181  ATHPRSASLS HPGGEGEPAR SRAPAPGTAG RGPLANQQRK WCFSEPGKLD RVGRGGGPAR
   241  ECLGEACSSS GLPGPEPLEF QHPALAKFED HEVGWLPETQ PQGSMNLDSG SLKLGDAFRP
   301  ASRSRSASGE VLGSWGGSGG TIPIVQAVPQ GAETPRPLFQ TKLSRFLPQK EAAVMYPAEL
   361  PQSSPADSEQ RVSETCIVPA WLPSLPDEVF LEEAPLVRMR SPPDPHASQG PPASVHASDQ
   421  PYGTGLGQRT GQVTVPTEYP LHECPGTAGA DDCWQGVNGS VGISRPTSHT PTGTANDNIP
   481  TIDPTGLTTN PPTAAESDLL KPVPADALGL SGNDTPGPSH NTALARGTGQ PGSRPTWPSQ
   541  CLEELVQELA RLDPSLCDPL ASQPSPEPPL GLLDGLIPLA EVRAAMRPAC GEAGEEAAST
   601  FEPGSYQFSF TQLLPAPREE TRLENPATHP VLDQPCGQGL PAPNNSIQGK KVELAARLQK
   661  MLQDLHTEQE RLQGEAQAWA RRQAALEAAV RQACAPQELE RFSRFMADLE RVLGLLLLLG
   721  SRLARVRRAL ARAASDSDPD EQASLLQRLR LLQRQEEDAK ELKEHVARRE RAVREVLVRA
   781  LPVEELRVYC ALLAGKAAVL AQQRNLDERI RLLQDQLDAI RDDLGHHAPS PSPARPPGTC
   841  PPVQPPFPLL LT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SHROOM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
112 nTPM

Expression across tissuesHPA

Tissue

  • liver: 112 nTPM
  • prostate: 67 nTPM
  • urinary bladder: 63 nTPM
  • spinal cord: 32 nTPM
  • colon: 19 nTPM
  • midbrain: 19 nTPM

Single-cell type

  • urothelial cells: 144 nCPM
  • prostatic club cells: 134 nCPM
  • colonocytes: 106 nCPM
  • hepatocytes: 87 nCPM
  • prostatic hillock cells: 85 nCPM
  • papillary tip epithelial cells: 74 nCPM

Immune cell

  • classical monocyte: 0.9 nTPM
  • intermediate monocyte: 0.2 nTPM
  • non-classical monocyte: 0.2 nTPM
  • total PBMC: 0.2 nTPM
  • basophil: 0.1 nTPM
  • neutrophil: 0.1 nTPM

Brain region

  • white matter: 102 nTPM
  • medulla oblongata: 79 nTPM
  • pons: 60 nTPM
  • basal ganglia: 56 nTPM
  • thalamus: 55 nTPM
  • midbrain: 55 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.54
gnomAD pLI
0.05
gnomAD missense Z
0.92
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SHROOM1 as an antibody target. Whether an autoantibody or antibody against SHROOM1 could matter depends on whether native SHROOM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SHROOM1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SHROOM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SHROOM1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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