Seroatlas · Human Serome Atlas

SHF

SH2 domain-containing adapter protein F

Also known as: SHF_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7M4L6
Gene: SHF
Ensembl: ENSG00000138606
Chromosome: 15
Canonical length: 423 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable phosphotyrosine residue binding activity. Predicted to be involved in apoptotic process. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

423 residues, UniProt reviewed canonical sequence.

>Q7M4L6|SHF
     1  MQQEGGPVRS APCRTGTLEG SRQGSPGHRK RASPKGSLSS AQPHSWMLTP SPLNSHCAHR
    61  EPISSSPQPV ANGPKQKKKS NWRSTTRLRI IRLRDRLEPR PLAILEDYAD PFDVQETGEG
   121  SAGASGAPEK VPENDGYMEP YEAQKMMAEI RGSKETATQP LPLYDTPYEP EEDGATAEGE
   181  GAPWPRESRL PEDDERPPEE YDQPWEWKKE RISKAFAVDI KVIKDLPWPP PVGQLDSSPS
   241  LPDGDRDISG PASPLPEPSL EDSSAQFEGP EKSCLSPGRE EKGRLPPRLS AGNPKSAKPL
   301  SMEPSSPLGE WTDPALPLEN QVWYHGAISR TDAENLLRLC KEASYLVRNS ETSKNDFSLS
   361  LKSSQGFMHM KLSRTKEHKY VLGQNSPPFS SVPEIVHHYA SRKLPIKGAE HMSLLYPVAI
   421  RTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SHF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 61 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 61 nTPM
liver: 37 nTPM
ovary: 27 nTPM
adrenal gland: 21 nTPM
cerebral cortex: 15 nTPM
cervix: 12 nTPM

Single-cell type

retinal bipolar cells: 43 nCPM
adrenal medulla cells: 43 nCPM
brain excitatory neurons: 41 nCPM
epicardial cells: 23 nCPM
late spermatids: 21 nCPM
breast myoepithelial cells: 21 nCPM

Immune cell

NK-cell: 2 nTPM
naive B-cell: 1.5 nTPM
MAIT T-cell: 1.4 nTPM
gdT-cell: 1.3 nTPM
plasmacytoid DC: 0.9 nTPM
memory B-cell: 0.8 nTPM

Brain region

cerebellum: 282 nTPM
cerebral cortex: 63 nTPM
basal ganglia: 52 nTPM
hypothalamus: 51 nTPM
hippocampal formation: 50 nTPM
amygdala: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.55
gnomAD pLI: 0.16
gnomAD missense Z: 0.87
DepMap mean gene effect: -0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

phosphotyrosine residue binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SHF as an antibody target. Whether an autoantibody or antibody against SHF could matter depends on whether native SHF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SHF is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SHF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...