Seroatlas · Human Serome Atlas

SHE

SH2 domain-containing adapter protein E

Also known as: SHE_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VZ18
Gene: SHE
Ensembl: ENSG00000169291
Chromosome: 1
Canonical length: 495 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable phosphotyrosine residue binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

495 residues, UniProt reviewed canonical sequence.

>Q5VZ18|SHE
     1  MQWSPTPGAS ACLGWASSLA CSTAPTLLGR AGRGPLMAAK WFKEFPLNLK TVSERAKPGG
    61  GGGKLRKNSE AGGAGPGPGK GRKNSAAELG SGRAGVGPKD SRLSRDSLQG LIQAAAGKGR
   121  KNSRATEEEP HRGATKSSGC STYINRLIKV DTQEKNGKSN YPSSSSSSSS SSSSASSSPS
   181  SLGPELDKGK IIKQQETVII LEDYADPYDA KRTKGQRDAE RVGENDGYME PYDAQQMITE
   241  IRRRGSKDPL VKALQLLDSP CEPADGGLKS ETLAKRRSSK DLLGKPPQLY DTPYEPAEGG
   301  PRAEGKARPP DSRLPENDER PAAEYEQPWE WKKEQIVRAL SVQFEGAERP SFREETVRQH
   361  HRQKSWTQKI LKPALSDHSE GEKVDPGLPL EKQPWYHGAI SRAEAESRLQ PCKEAGYLVR
   421  NSESGNSRYS IALKTSQGCV HIIVAQTKDN KYTLNQTSAV FDSIPEVVHY YSNEKLPFKG
   481  AEHMTLLYPV HSKLH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SHE can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 22 nTPM
heart muscle: 22 nTPM
testis: 21 nTPM
thyroid gland: 21 nTPM
spleen: 21 nTPM
breast: 20 nTPM

Single-cell type

vascular endothelial cells: 116 nCPM
lymphatic endothelial cells: 95 nCPM
kupffer cells: 75 nCPM
sertoli cells: 53 nCPM
epicardial cells: 41 nCPM
thymic myoid cells: 37 nCPM

Immune cell

plasmacytoid DC: 4 nTPM
neutrophil: 2.4 nTPM
NK-cell: 1.7 nTPM
gdT-cell: 1.5 nTPM
intermediate monocyte: 1.5 nTPM
MAIT T-cell: 1.1 nTPM

Brain region

thalamus: 12 nTPM
amygdala: 10 nTPM
midbrain: 9.6 nTPM
pons: 9.1 nTPM
basal ganglia: 8.9 nTPM
cerebral cortex: 8.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.28
gnomAD pLI: 0.99
gnomAD missense Z: 0.77
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

phosphotyrosine residue binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SHE as an antibody target. Whether an autoantibody or antibody against SHE could matter depends on whether native SHE is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SHE is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SHE as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...