Seroatlas · Human Serome Atlas

SHD

SH2 domain-containing adapter protein D

Also known as: SHD_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96IW2
Gene: SHD
Ensembl: ENSG00000105251
Chromosome: 19
Canonical length: 340 aa
Protein class: Predicted intracellular proteins
Subcellular location: Centriolar satellite,Cytosol

OverviewNCBI Gene

Predicted to enable phosphotyrosine residue binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

340 residues, UniProt reviewed canonical sequence.

>Q96IW2|SHD
     1  MAKWLRDYLS FGGRRPPPQP PTPDYTESDI LRAYRAQKNL DFEDPYEDAE SRLEPDPAGP
    61  GDSKNPGDAK YGSPKHRLIK VEAADMARAK ALLGGPGEEL EADTEYLDPF DAQPHPAPPD
   121  DGYMEPYDAQ WVMSELPGRG VQLYDTPYEE QDPETADGPP SGQKPRQSRM PQEDERPADE
   181  YDQPWEWKKD HISRAFAVQF DSPEWERTPG SAKELRRPPP RSPQPAERVD PALPLEKQPW
   241  FHGPLNRADA ESLLSLCKEG SYLVRLSETN PQDCSLSLRS SQGFLHLKFA RTRENQVVLG
   301  QHSGPFPSVP ELVLHYSSRP LPVQGAEHLA LLYPVVTQTP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SHD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 21 nTPM
cerebral cortex: 13 nTPM
hypothalamus: 5.9 nTPM
midbrain: 5.3 nTPM
amygdala: 5.2 nTPM
cerebellum: 5 nTPM

Single-cell type

oocytes: 926 nCPM
colonocytes: 130 nCPM
pdcs: 91 nCPM
hepatocytes: 62 nCPM
goblet cells: 51 nCPM
enteric transient amplifying cells: 50 nCPM

Immune cell

plasmacytoid DC: 18 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

thalamus: 22 nTPM
hypothalamus: 21 nTPM
cerebral cortex: 19 nTPM
medulla oblongata: 16 nTPM
cerebellum: 16 nTPM
midbrain: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.13
gnomAD pLI: 0
gnomAD missense Z: -0.43
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

phosphotyrosine residue binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SHD as an antibody target. Whether an autoantibody or antibody against SHD could matter depends on whether native SHD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SHD is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SHD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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