Seroatlas · Human Serome Atlas

SHANK2-AS3

Putative uncharacterized protein SHANK2-AS3

Also known as: SHAS3_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BTD1
Gene: SHANK2-AS3
Canonical length: 123 aa

OverviewNCBI Gene

No narrative summary is available for SHANK2-AS3 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

123 residues, UniProt reviewed canonical sequence.

>Q9BTD1|SHANK2-AS3
     1  MAQLPSAQMP APRTQPDLIL VHPVLALSGR APSILCSVPW DACELLATAM WWKTRILWGV
    61  FLISRTRPPA PMQILILTLD PSEGEVCCKK RKPGQTGRNR VRMTTATCKP GGEASGETSP
   121  GTP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SHANK2-AS3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SHANK2-AS3 as an antibody target. Whether an autoantibody or antibody against SHANK2-AS3 could matter depends on whether native SHANK2-AS3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SHANK2-AS3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SHANK2-AS3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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