Seroatlas · Human Serome Atlas

SH2D7

SH2 domain-containing protein 7

Also known as: LOC646892, SH2D7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NKC9
Gene: SH2D7
Ensembl: ENSG00000183476
Chromosome: 15
Canonical length: 451 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

451 residues, UniProt reviewed canonical sequence.

>A6NKC9|SH2D7
     1  MEDSLKQLSL GRDPEGAGDS QALAELQELA LKWFMETQAP FILQNGALPP WFHGFITRKQ
    61  TEQLLRDKAL GSFLIRLSDR ATGYILSYRG SDRCRHFVIN QLRNRRYIIS GDTQSHSTLA
   121  ELVHHYQEAQ LEPFKEMLTA ACPRPEDNDL YDAITRGLHQ TIVDPENPPA TAFLTVVPDK
   181  AASPRSSPKP QVSFLHAQKS LDVSPRNLSQ EESMEAPIRV SPLPEKSSSL LEESFGGPSD
   241  IIYADLRRMN QARLGLGTEG SGRHGPVPAG SQAYSPGREA QRRLSDGEQN RPDGLGPVLS
   301  GVSPDQGPTE SPTSWGCSDA MGSLGATWRQ EFPKLSQEAQ PCSQGSSADI YEFIGTEGLL
   361  QEARDTPDQE GSTYEQIPAC WGGPARAPHP GASPTYSPWV HGYKRISGTP ELSEPGNTYE
   421  QIPATKSKET GRTHKPDKLR RLFFTYRKHK F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SH2D7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 2.9 nTPM

Expression across tissuesHPA

Tissue

testis: 2.9 nTPM
duodenum: 2.2 nTPM
colon: 1.7 nTPM
small intestine: 1.7 nTPM
appendix: 0.2 nTPM
cerebral cortex: 0.2 nTPM

Single-cell type

tuft cells: 1,003 nCPM
late primary spermatocytes: 393 nCPM
early spermatids: 243 nCPM
late spermatids: 225 nCPM
early primary spermatocytes: 5.7 nCPM
sertoli cells: 3.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 1.8 nTPM
amygdala: 1.5 nTPM
spinal cord: 1.5 nTPM
cerebral cortex: 1.4 nTPM
basal ganglia: 1.3 nTPM
cerebellum: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.19
gnomAD pLI: 0
gnomAD missense Z: 0.1
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

SH2 domain

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SH2D7 as an antibody target. Whether an autoantibody or antibody against SH2D7 could matter depends on whether native SH2D7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SH2D7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SH2D7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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