Seroatlas · Human Serome Atlas

SH2D6

SH2 domain-containing protein 6

Also known as: SH2D6_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z4S9
Gene: SH2D6
Canonical length: 335 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for SH2D6 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

335 residues, UniProt reviewed canonical sequence.

>Q7Z4S9|SH2D6
     1  MDKLSGSRPR LGPPLPPPRC VDSPGWREDA PSPSFLPAPG TWRHKAQEED EEENKYELPP
    61  CEALPLSLAP AHLPGTEEDS LYLDHSGPLG PSKPSPPLPQ PTMLKGAVSL PVAGKQGPIF
   121  GRREQGASSR VVPGPPKKPD EDLYLECEPD PVLALTQTLS FQVLMPSGPL PRTSVVPRPT
   181  TAPQETRNGT ADAASKEGRK SSLPSVAPTG SASAAEDSDL LTQPWYSGNC DRYAVESALL
   241  HLQKDGAYTV RPSSGPHGSQ PFTLAVLLRG RVFNIPIRRL DGGRHYALGR EGRNREELFS
   301  SVAAMVQHFM WHPLPLVDRH SGSRELTCLL FPTKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SH2D6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 2.8 nTPM

Expression across tissuesHPA

Tissue

duodenum: 2.8 nTPM
small intestine: 1.9 nTPM
testis: 1.7 nTPM
colon: 1.3 nTPM
stomach: 0.4 nTPM
pancreas: 0.3 nTPM

Single-cell type

tuft cells: 2,709 nCPM
myosatellite cells: 12 nCPM
adrenal medulla cells: 11 nCPM
somatotrophs: 9 nCPM
lactotrophs: 8.6 nCPM
early primary spermatocytes: 7.8 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 1.2 nTPM
white matter: 1.2 nTPM
basal ganglia: 1.1 nTPM
pons: 1.1 nTPM
medulla oblongata: 0.9 nTPM
thalamus: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.65
gnomAD pLI: 0
gnomAD missense Z: 0.47
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

SH2 domain

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SH2D6 as an antibody target. Whether an autoantibody or antibody against SH2D6 could matter depends on whether native SH2D6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SH2D6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SH2D6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...