Seroatlas · Human Serome Atlas

SH2D5

SH2 domain-containing protein 5

Also known as: SH2D5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZV89
Gene: SH2D5
Ensembl: ENSG00000189410
Chromosome: 1
Canonical length: 423 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to be located in synapse. Predicted to be active in postsynaptic density. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

423 residues, UniProt reviewed canonical sequence.

>Q6ZV89|SH2D5
     1  MQKAGAGGRR ASDCGLAPHR PRCITKFAQY VGSFPVDDLD TQESVWLVQQ QLWALKDCPR
    61  RRAVILKFSL QGLKIYSGEG EVLLMAHALR RILYSTWCPA DCQFAFMARN PRSPASKLFC
   121  HLFVGSQPGE VQILHLLLCR SFQLAYLLQH PEERAQPEPC PGPTGEVPLK PLSSSGGLVR
   181  EPFGRDQLSQ NVHALVSFRR LPAEGLVGSG KELPESEGRA RHARLGNPYC SPTLVRKKAI
   241  RSKVIRSGAY RGCTYETQLQ LSAREAFPAA WEAWPRGPGG HSCLVESEGS LTENIWAFAG
   301  ISRPCALALL RRDVLGAFLL WPELGASGQW CLSVRTQCGV VPHQVFRNHL GRYCLEHLPA
   361  EFPSLEALVE NHAVTERSLF CPLDMGRLNP TYEEQDCGPP GRPPRTLRPL SHAKSEAELQ
   421  GLG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SH2D5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 17 nTPM
cerebral cortex: 13 nTPM
testis: 6.9 nTPM
amygdala: 4.1 nTPM
hypothalamus: 3.7 nTPM
hippocampal formation: 3.5 nTPM

Single-cell type

brain inhibitory neurons: 14 nCPM
brain excitatory neurons: 7.3 nCPM
syncytiotrophoblasts: 7.3 nCPM
other brain neurons: 6.3 nCPM
epicardial cells: 4.5 nCPM
basal keratinocytes: 3.9 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 95 nTPM
cerebral cortex: 74 nTPM
hippocampal formation: 56 nTPM
amygdala: 54 nTPM
thalamus: 43 nTPM
white matter: 42 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0
gnomAD missense Z: 0.68
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

postsynaptic density

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SH2D5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SH2D5 as an antibody target. Whether an autoantibody or antibody against SH2D5 could matter depends on whether native SH2D5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SH2D5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SH2D5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...