Seroatlas · Human Serome Atlas

SH2D4B

SH2 domain-containing protein 4B

Also known as: SH24B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5SQS7
Gene: SH2D4B
Ensembl: ENSG00000178217
Chromosome: 10
Canonical length: 431 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

431 residues, UniProt reviewed canonical sequence.

>Q5SQS7|SH2D4B
     1  MLQQILHDMY IDPELLAELS DVQKHILFYK MREEQLRRWK ERETWEALAQ DEGLRPPKTK
    61  RASDKHIQWL LGADGEVWVW IMGEGPGDKP YEEISEELIA ERARLQAQRE AEELWRQKEA
   121  EITKKFRDAL ANEKARILAE KWKVEMEDRK AAKVLEERIH EEFKRKEEEE RKRGEEQIRL
   181  QEEQRAKELY WTLKQAQLHC QASEKEEREW EEQLRRSKAA DEERSRRAQR ARDEYRHHSL
   241  RAIQKGTVAG LSSMFRELGQ SHEQEARLYH HLPDPGLPQP LALPVRTWER PLRPVSRDVI
   301  VRWFKEEQLP RRAGFERNTK FIAPWFHGII SREDAEALLE NMTEGAFLVR VSEKIWGYTL
   361  SYRLQKGFKH FLVDASGDFY SFLGVDPNRH ATLTDLVDFH KEEIITVSGG ELLQEPCGQR
   421  DSPPDYHLLF E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SH2D4B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 0.3 nTPM

Expression across tissuesHPA

Tissue

epididymis: 0.3 nTPM
testis: 0.3 nTPM
bone marrow: 0.2 nTPM
lung: 0.2 nTPM
thymus: 0.2 nTPM
adipose tissue: 0 nTPM

Single-cell type

epididymal clear cells: 35 nCPM
endometrial secretory cells: 26 nCPM
endometrial luminal cells: 14 nCPM
late primary spermatocytes: 12 nCPM
undifferentiated spermatogonia: 11 nCPM
neutrophils: 10 nCPM

Immune cell

neutrophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 0.5 nTPM
amygdala: 0.4 nTPM
basal ganglia: 0.4 nTPM
hippocampal formation: 0.3 nTPM
thalamus: 0.3 nTPM
white matter: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.86
gnomAD pLI: 0
gnomAD missense Z: 0.1
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

SH2 domain

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SH2D4B as an antibody target. Whether an autoantibody or antibody against SH2D4B could matter depends on whether native SH2D4B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SH2D4B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SH2D4B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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