Seroatlas · Human Serome Atlas

SGPP2

Sphingosine-1-phosphate phosphatase 2

Also known as: FLJ39004, SGPP2_HUMAN, SPP2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IWX5
Gene: SGPP2
Ensembl: ENSG00000163082
Chromosome: 2
Canonical length: 399 aa
Protein class: Metabolic proteins, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene is a transmembrane protein that degrades the bioactive signaling molecule sphingosine 1-phosphate. The encoded protein is induced during inflammatory responses and has been shown to be downregulated by the microRNA-31 tumor suppressor. Alternative splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016]

Canonical amino-acid sequenceUniProt

399 residues, UniProt reviewed canonical sequence.

>Q8IWX5|SGPP2
     1  MAELLRSLQD SQLVARFQRR CGLFPAPDEG PRENGADPTE RAARVPGVEH LPAANGKGGE
    61  APANGLRRAA APEAYVQKYV VKNYFYYYLF QFSAALGQEV FYITFLPFTH WNIDPYLSRR
   121  LIIIWVLVMY IGQVAKDVLK WPRPSSPPVV KLEKRLIAEY GMPSTHAMAA TAIAFTLLIS
   181  TMDRYQYPFV LGLVMAVVFS TLVCLSRLYT GMHTVLDVLG GVLITALLIV LTYPAWTFID
   241  CLDSASPLFP VCVIVVPFFL CYNYPVSDYY SPTRADTTTI LAAGAGVTIG FWINHFFQLV
   301  SKPAESLPVI QNIPPLTTYM LVLGLTKFAV GIVLILLVRQ LVQNLSLQVL YSWFKVVTRN
   361  KEARRRLEIE VPYKFVTYTS VGICATTFVP MLHRFLGLP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SGPP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 9
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 25 nTPM
stomach: 24 nTPM
esophagus: 23 nTPM
skin: 23 nTPM
urinary bladder: 21 nTPM
thyroid gland: 20 nTPM

Single-cell type

alveolar cells type 2: 1,019 nCPM
endometrial glandular cells: 766 nCPM
urothelial cells: 601 nCPM
transitional alveolar cells: 458 nCPM
endometrial luminal cells: 423 nCPM
fallopian secretory cells: 343 nCPM

Immune cell

T-reg: 0.6 nTPM
basophil: 0.3 nTPM
memory CD4 T-cell: 0.3 nTPM
memory B-cell: 0.2 nTPM
MAIT T-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM

Brain region

pons: 37 nTPM
thalamus: 32 nTPM
cerebellum: 31 nTPM
cerebral cortex: 31 nTPM
medulla oblongata: 29 nTPM
hypothalamus: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0
gnomAD missense Z: 0.07
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SGPP2 as an antibody target. Whether an autoantibody or antibody against SGPP2 could matter depends on whether native SGPP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SGPP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SGPP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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