Seroatlas · Human Serome Atlas

SGPP1

Sphingosine-1-phosphate phosphatase 1

Also known as: SGPP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BX95
Gene
SGPP1
Ensembl
ENSG00000126821
Chromosome
14
Canonical length
441 aa
Protein class
Metabolic proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP1 catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides (Mandala et al., 2000 [PubMed 10859351]; Le Stunff et al., 2007 [PubMed 17895250]).[supplied by OMIM, Jun 2009]

Canonical amino-acid sequenceUniProt

441 residues, UniProt reviewed canonical sequence.

>Q9BX95|SGPP1
     1  MSLRQRLAQL VGRLQDPQKV ARFQRLCGVE APPRRSADRR EDEKAEAPLA GDPRLRGRQP
    61  GAPGGPQPPG SDRNQCPAKP DGGGAPNGVR NGLAAELGPA SPRRAGALRR NSLTGEEGQL
   121  ARVSNWPLYC LFCFGTELGN ELFYILFFPF WIWNLDPLVG RRLVVIWVLV MYLGQCTKDI
   181  IRWPRPASPP VVKLEVFYNS EYSMPSTHAM SGTAIPISMV LLTYGRWQYP LIYGLILIPC
   241  WCSLVCLSRI YMGMHSILDI IAGFLYTILI LAVFYPFVDL IDNFNQTHKY APFIIIGLHL
   301  ALGIFSFTLD TWSTSRGDTA EILGSGAGIA CGSHVTYNMG LVLDPSLDTL PLAGPPITVT
   361  LFGKAILRIL IGMVFVLIIR DVMKKITIPL ACKIFNIPCD DIRKARQHME VELPYRYITY
   421  GMVGFSITFF VPYIFFFIGI S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SGPP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
9
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • liver: 18 nTPM
  • spinal cord: 16 nTPM
  • kidney: 15 nTPM
  • lymph node: 12 nTPM
  • tonsil: 12 nTPM
  • pancreas: 12 nTPM

Single-cell type

  • renal connecting tubule cells: 382 nCPM
  • renal collecting duct principal cells: 225 nCPM
  • distal convoluted tubule cells: 187 nCPM
  • proximal tubule cells: 91 nCPM
  • microglia: 89 nCPM
  • oligodendrocytes: 77 nCPM

Immune cell

  • basophil: 6.9 nTPM
  • non-classical monocyte: 2.1 nTPM
  • memory B-cell: 1.8 nTPM
  • eosinophil: 1.7 nTPM
  • intermediate monocyte: 1.4 nTPM
  • T-reg: 1.3 nTPM

Brain region

  • white matter: 14 nTPM
  • spinal cord: 12 nTPM
  • medulla oblongata: 11 nTPM
  • midbrain: 10 nTPM
  • hypothalamus: 9.4 nTPM
  • basal ganglia: 9.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.07
gnomAD pLI
0
gnomAD missense Z
0.65
DepMap mean gene effect
-0.15
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SGPP1 as an antibody target. Whether an autoantibody or antibody against SGPP1 could matter depends on whether native SGPP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SGPP1 is annotated at the cell surface, where native SGPP1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SGPP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SGPP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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