Seroatlas · Human Serome Atlas

SGCZ

Zeta-sarcoglycan

Also known as: SGCZ_HUMAN, ZSG1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96LD1
Gene: SGCZ
Ensembl: ENSG00000185053
Chromosome: 8
Canonical length: 299 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

The zeta-sarcoglycan gene measures over 465 kb and localizes to 8p22. This protein is part of the sarcoglycan complex, a group of 6 proteins. The sarcoglycans are all N-glycosylated transmembrane proteins with a short intra-cellular domain, a single transmembrane region and a large extra-cellular domain containing a carboxyl-terminal cluster with several conserved cysteine residues. The sarcoglycan complex is part of the dystrophin-associated glycoprotein complex (DGC), which bridges the inner cytoskeleton and the extra-cellular matrix. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

299 residues, UniProt reviewed canonical sequence.

>Q96LD1|SGCZ
     1  MTREQYILAT QQNNLPRTEN AQLYPVGIYG WRKRCLYFFV LLLLVTMIVN LAMTIWILKV
    61  MNFTVDGMGN LRVTKKGIRL EGISEFLLPL YVKEIHSRKD SPLVLQSDRN VTVNARNHMG
   121  QLTGQLTIGA DAVEAQCKRF EVRASEDGRV LFSADEDEIT IGAEKLKVTG TEGAVFGHSV
   181  ETPHIRAEPS QDLRLESPTR SLIMEAPRGV QVSAAAGDFK ATCRKELHLQ STEGEIFLNA
   241  ETIKLGNLPT GSFSSSSPSS SSSRQTVYEL CVCPNGKLYL SPAGVGSTCQ SSSNICLWS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SGCZ can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 1.2 nTPM

Expression across tissuesHPA

Tissue

ovary: 1.2 nTPM
cerebral cortex: 0.5 nTPM
basal ganglia: 0.4 nTPM
cerebellum: 0.4 nTPM
hypothalamus: 0.4 nTPM
amygdala: 0.3 nTPM

Single-cell type

corticotrophs: 1,756 nCPM
brain inhibitory neurons: 1,645 nCPM
oligodendrocyte progenitor cells: 1,507 nCPM
medullary thymic epithelial cells: 1,325 nCPM
other brain neurons: 1,172 nCPM
brain excitatory neurons: 895 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 6.6 nTPM
midbrain: 6.2 nTPM
cerebellum: 5.1 nTPM
cerebral cortex: 4.1 nTPM
amygdala: 3.4 nTPM
basal ganglia: 3.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.19
gnomAD pLI: 0
gnomAD missense Z: -1.02
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SGCZ as an antibody target. Whether an autoantibody or antibody against SGCZ could matter depends on whether native SGCZ is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SGCZ is annotated at the cell surface, where native SGCZ is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SGCZ as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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