Seroatlas · Human Serome Atlas

SFTA3

Surfactant-associated protein 3

Also known as: SFTA3_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0C7M3
Gene: SFTA3
Canonical length: 94 aa

OverviewNCBI Gene

No narrative summary is available for SFTA3 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

94 residues, UniProt reviewed canonical sequence.

>P0C7M3|SFTA3
     1  MRAGFSDFQL IRDQVLFLQD QAQRLTEWLQ LSGFENPVSE STTLCLRERE KRIPTCVAVC
    61  VPSPGTVHTA LLHPTTLSQS RSSSEAKMLI IHTA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SFTA3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0.39
gnomAD missense Z: 0.57

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

wound healing

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SFTA3 as an antibody target. Whether an autoantibody or antibody against SFTA3 could matter depends on whether native SFTA3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SFTA3 is annotated as secreted, so native SFTA3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SFTA3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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