Seroatlas · Human Serome Atlas

SFTA2

Surfactant-associated protein 2

Also known as: SFTA2_HUMAN, SFTPG, SP-G

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6UW10
Gene
SFTA2
Ensembl
ENSG00000196260
Chromosome
6
Canonical length
78 aa
Protein class
Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted in other tissues

OverviewNCBI Gene

Predicted to be located in Golgi apparatus; extracellular region; and transport vesicle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

78 residues, UniProt reviewed canonical sequence.

>Q6UW10|SFTA2
     1  MGSGLPLVLL LTLLGSSHGT GPGMTLQLKL KESFLTNSSY ESSFLELLEK LCLLLHLPSG
    61  TSVTLHHARS QHHVVCNT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SFTA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
179 nTPM

Expression across tissuesHPA

Tissue

  • lung: 179 nTPM
  • esophagus: 49 nTPM
  • vagina: 21 nTPM
  • cervix: 15 nTPM
  • kidney: 8.2 nTPM
  • stomach: 7.8 nTPM

Single-cell type

  • alveolar cells type 2: 861 nCPM
  • esophageal apical cells: 809 nCPM
  • transitional alveolar cells: 477 nCPM
  • alveolar cells type 1: 413 nCPM
  • cholangiocytes: 50 nCPM
  • endometrial ciliated cells: 48 nCPM

Immune cell

  • naive CD8 T-cell: 0.3 nTPM
  • memory CD4 T-cell: 0.2 nTPM
  • naive B-cell: 0.2 nTPM
  • naive CD4 T-cell: 0.2 nTPM
  • memory B-cell: 0.1 nTPM
  • memory CD8 T-cell: 0.1 nTPM

Brain region

  • basal ganglia: 0.5 nTPM
  • spinal cord: 0.5 nTPM
  • cerebellum: 0.4 nTPM
  • hippocampal formation: 0.4 nTPM
  • hypothalamus: 0.4 nTPM
  • medulla oblongata: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.79
gnomAD pLI
0.04
gnomAD missense Z
0.31
DepMap mean gene effect
-0.28
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Surfactant-associated protein 2
  • Surfactant-associated protein 2

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SFTA2 as an antibody target. Whether an autoantibody or antibody against SFTA2 could matter depends on whether native SFTA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SFTA2 is annotated as secreted, so native SFTA2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SFTA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SFTA2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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