Seroatlas · Human Serome Atlas

SFRP5

Secreted frizzled-related protein 5

Also known as: SARP3, SFRP5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T4F7
Gene: SFRP5
Ensembl: ENSG00000120057
Chromosome: 10
Canonical length: 317 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted in other tissues

OverviewNCBI Gene

Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

317 residues, UniProt reviewed canonical sequence.

>Q5T4F7|SFRP5
     1  MRAAAAGGGV RTAALALLLG ALHWAPARCE EYDYYGWQAE PLHGRSYSKP PQCLDIPADL
    61  PLCHTVGYKR MRLPNLLEHE SLAEVKQQAS SWLPLLAKRC HSDTQVFLCS LFAPVCLDRP
   121  IYPCRSLCEA VRAGCAPLME AYGFPWPEML HCHKFPLDND LCIAVQFGHL PATAPPVTKI
   181  CAQCEMEHSA DGLMEQMCSS DFVVKMRIKE IKIENGDRKL IGAQKKKKLL KPGPLKRKDT
   241  KRLVLHMKNG AGCPCPQLDS LAGSFLVMGR KVDGQLLLMA VYRWDKKNKE MKFAVKFMFS
   301  YPCSLYYPFF YGAAEPH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SFRP5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 216 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 216 nTPM
pancreas: 135 nTPM
heart muscle: 72 nTPM
colon: 34 nTPM
duodenum: 28 nTPM
small intestine: 25 nTPM

Single-cell type

retinal pigment epithelial cells: 529 nCPM
pancreatic duct cells: 353 nCPM
cholangiocytes: 307 nCPM
schwann cells: 121 nCPM
epididymal basal cells: 52 nCPM
enterocytes: 37 nCPM

Immune cell

naive CD8 T-cell: 3.6 nTPM
plasmacytoid DC: 0.8 nTPM
naive CD4 T-cell: 0.3 nTPM
total PBMC: 0.2 nTPM
memory CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM

Brain region

choroid plexus: 204 nTPM
thalamus: 31 nTPM
midbrain: 18 nTPM
hypothalamus: 17 nTPM
hippocampal formation: 13 nTPM
basal ganglia: 8.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.43
gnomAD pLI: 0
gnomAD missense Z: 0.63
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Wnt-protein binding

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SFRP5 as an antibody target. Whether an autoantibody or antibody against SFRP5 could matter depends on whether native SFRP5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SFRP5 is annotated as secreted, so native SFRP5 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SFRP5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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