SETSIP
Protein SETSIP
Also known as: SETLP_HUMAN, SETP18
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P0DME0
- Gene
- SETSIP
- Ensembl
- ENSG00000230667
- Chromosome
- 1
- Canonical length
- 292 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Lipid droplets
OverviewNCBI Gene
Enables chromatin binding activity. Involved in endothelial cell differentiation and positive regulation of transcription by RNA polymerase II. Located in cytoplasm; lipid droplet; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
292 residues, UniProt reviewed canonical sequence.
>P0DME0|SETSIP
1 MAPKRQSPLP LQKKKPRPPP ALGLEETSAS AGLPKKGEKE QQEAIEHIDE VQNEIDRLNE
61 QDSEEILKVE QKYNKLRQPF FQKRSELIAK IPNFGVTTFV NHPQVSSLLG EEDEEALHYL
121 TKVEVTEFED IKSGYRIDFY FDENPYFENK VFSKEFHLNE SGDPSSKSTK IKWKSGKDVT
181 KRSSQTQNKA SRKRQHEEPE SFFTWFTDHS DAGADELEEV IKDDIWPNPL QYYLVPDMDD
241 EEGGEDDDDD DDDGDEGEEE LEDIDEGDED EGEEDEDDDE GEEGEEDEGE DDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SETSIP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.46
- Highest tissue expression
- 0.2 nTPM
Expression across tissuesHPA
Tissue
- cerebral cortex: 0.2 nTPM
- testis: 0.2 nTPM
- adipose tissue: 0.1 nTPM
- amygdala: 0.1 nTPM
- basal ganglia: 0.1 nTPM
- blood vessel: 0.1 nTPM
Single-cell type
- late primary spermatocytes: 1.9 nCPM
- early spermatids: 1.6 nCPM
- podocytes: 0.8 nCPM
- renal collecting duct principal cells: 0.6 nCPM
- papillary tip epithelial cells: 0.5 nCPM
- loop of henle epithelial cells: 0.4 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 2.2 nTPM
- white matter: 1.8 nTPM
- basal ganglia: 1.2 nTPM
- cerebellum: 1.1 nTPM
- hypothalamus: 1 nTPM
- amygdala: 0.9 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about SETSIP.
Disease | GeneticClinVar
1 pathogenic / likely-pathogenic of 1 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
OntologyGO
Biological processes
- endothelial cell differentiation
- nucleosome assembly
- positive regulation of transcription by RNA polymerase II
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SETSIP as an antibody target. Whether an autoantibody or antibody against SETSIP could matter depends on whether native SETSIP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SETSIP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SETSIP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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