Seroatlas · Human Serome Atlas

SERHL2

Serine hydrolase-like protein 2

Also known as: SEHL2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H4I8
Gene: SERHL2
Ensembl: ENSG00000183569
Chromosome: 22
Canonical length: 314 aa
Protein class: Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable hydrolase activity. Predicted to be located in cytoplasmic vesicle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

314 residues, UniProt reviewed canonical sequence.

>Q9H4I8|SERHL2
     1  MSENAAPGLI SELKLAVPWG HIAAKAWGSL QGPPVLCLHG WLDNASSFDR LIPLLPQDFY
    61  YVAMDFGGHG LSSHYSPGVP YYLQTFVSEI RRVVAALKWN RFSILGHSFG GVVGGMFFCT
   121  FPEMVDKLIL LDTPLFLLES DEMENLLTYK RRAIEHVLQV EASQEPSHVF SLKQLLQRLL
   181  KSNSHLSEEC GELLLQRGTT KVATGLVLNR DQRLAWAENS IDFISRELCA HSIRKLQAHV
   241  LLIKAVHGYF DSRQNYSEKE SLSFMIDTMK STLKEQFQFV EVPGNHCVHM SEPQHVASII
   301  SSFLQCTHML PAQL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SERHL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 399 nTPM

Expression across tissuesHPA

Tissue

breast: 399 nTPM
epididymis: 34 nTPM
ovary: 17 nTPM
skin: 14 nTPM
prostate: 11 nTPM
salivary gland: 9 nTPM

Single-cell type

epicardial cells: 80 nCPM
oocytes: 78 nCPM
epididymal principal cells: 50 nCPM
cardiomyocytes: 50 nCPM
renal collecting duct principal cells: 28 nCPM
breast hormone-responsive cells: 25 nCPM

Immune cell

naive B-cell: 9 nTPM
plasmacytoid DC: 4.3 nTPM
memory B-cell: 3.7 nTPM
eosinophil: 0.7 nTPM
naive CD8 T-cell: 0.7 nTPM
gdT-cell: 0.6 nTPM

Brain region

basal ganglia: 17 nTPM
cerebellum: 16 nTPM
cerebral cortex: 13 nTPM
hypothalamus: 11 nTPM
white matter: 11 nTPM
amygdala: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.95
gnomAD pLI: 0
gnomAD missense Z: -2.02
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

hydrolase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SERHL2 as an antibody target. Whether an autoantibody or antibody against SERHL2 could matter depends on whether native SERHL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SERHL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SERHL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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