SERF2
Small EDRK-rich factor 2
Also known as: 4F5REL, FAM2C, H4F5rel, HsT17089, SERF2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P84101
- Gene
- SERF2
- Ensembl
- ENSG00000140264
- Chromosome
- 15
- Canonical length
- 59 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nucleoli
OverviewNCBI Gene
Involved in protein destabilization. Predicted to be located in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
59 residues, UniProt reviewed canonical sequence.
>P84101|SERF2
1 MTRGNQRELA RQKNMKKQSD SVKGKRRDDG LSAAARKQRD SEIMQQKQKK ANEKKEEPKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SERF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.54
- Highest tissue expression
- 2,158 nTPM
Expression across tissuesHPA
Tissue
- choroid plexus: 2,158 nTPM
- liver: 1,285 nTPM
- heart muscle: 1,159 nTPM
- adrenal gland: 1,068 nTPM
- kidney: 1,056 nTPM
- blood vessel: 927 nTPM
Single-cell type
- esophageal apical cells: 6,820 nCPM
- parietal cells: 5,366 nCPM
- esophageal suprabasal cells: 5,192 nCPM
- extravillous trophoblasts: 4,408 nCPM
- platelets: 4,270 nCPM
- hofbauer cells: 3,926 nCPM
Immune cell
- total PBMC: 12,878 nTPM
- plasmacytoid DC: 6,505 nTPM
- eosinophil: 5,906 nTPM
- classical monocyte: 5,413 nTPM
- intermediate monocyte: 5,070 nTPM
- myeloid DC: 4,660 nTPM
Brain region
- choroid plexus: 954 nTPM
- thalamus: 396 nTPM
- white matter: 384 nTPM
- cerebellum: 369 nTPM
- spinal cord: 352 nTPM
- medulla oblongata: 343 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.41
- gnomAD pLI
- 0.02
- gnomAD missense Z
- 0.23
- DepMap mean gene effect
- -0.25
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SERF2 as an antibody target. Whether an autoantibody or antibody against SERF2 could matter depends on whether native SERF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SERF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SERF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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