Seroatlas · Human Serome Atlas

SENP8

Sentrin-specific protease 8

Also known as: DEN1, HsT17512, NEDP1, PRSC2, SENP8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96LD8
Gene: SENP8
Ensembl: ENSG00000166192
Chromosome: 15
Canonical length: 212 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

This gene encodes a cysteine protease that is a member of the sentrin-specific protease family. The encoded protein is involved in processing and deconjugation of the ubiquitin-like protein termed, neural precursor cell expressed developmentally downregulated 8. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

212 residues, UniProt reviewed canonical sequence.

>Q96LD8|SENP8
     1  MDPVVLSYMD SLLRQSDVSL LDPPSWLNDH IIGFAFEYFA NSQFHDCSDH VSFISPEVTQ
    61  FIKCTSNPAE IAMFLEPLDL PNKRVVFLAI NDNSNQAAGG THWSLLVYLQ DKNSFFHYDS
   121  HSRSNSVHAK QVAEKLEAFL GRKGDKLAFV EEKAPAQQNS YDCGMYVICN TEALCQNFFR
   181  QQTESLLQLL TPAYITKKRG EWKDLITTLA KK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SENP8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

testis: 15 nTPM
skeletal muscle: 5.9 nTPM
tongue: 5.3 nTPM
thyroid gland: 4.7 nTPM
retina: 4.3 nTPM
kidney: 4.1 nTPM

Single-cell type

late spermatids: 450 nCPM
cardiomyocytes: 210 nCPM
early spermatids: 123 nCPM
epicardial cells: 107 nCPM
oocytes: 41 nCPM
late primary spermatocytes: 39 nCPM

Immune cell

NK-cell: 3.6 nTPM
non-classical monocyte: 3.3 nTPM
myeloid DC: 2.9 nTPM
intermediate monocyte: 2.2 nTPM
memory B-cell: 1.9 nTPM
naive CD8 T-cell: 1.8 nTPM

Brain region

amygdala: 20 nTPM
cerebral cortex: 20 nTPM
white matter: 19 nTPM
hypothalamus: 19 nTPM
hippocampal formation: 19 nTPM
basal ganglia: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.74
gnomAD pLI: 0
gnomAD missense Z: 1.28
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

Ulp1 protease family, C-terminal catalytic domain
Papain-like cysteine peptidase superfamily
Ulp1 protease family, C-terminal catalytic domain
NEDD8-specific protease 1/2-like

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SENP8 as an antibody target. Whether an autoantibody or antibody against SENP8 could matter depends on whether native SENP8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SENP8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SENP8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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