SELENOP

Protein identityUniProt · HPA

UniProt accession

P49908

Gene

SELENOP

Ensembl

ENSG00000250722

Chromosome

5

Canonical length

381 aa

Protein class

Plasma proteins, Predicted membrane proteins, Predicted secreted proteins

Subcellular location

Nucleoplasm,Golgi apparatus,Connecting piece

Secretome location

Secreted to blood

OverviewNCBI Gene

This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in human), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. The use of alternative polyadenylation sites, one located in between the two SECIS elements, results in two populations of mRNAs containing either both (predominant) or just the upstream SECIS element (PMID:27881738). Alternatively spliced transcript variants have also been found for this gene. [provided by RefSeq, Oct 2018]

Canonical amino-acid sequenceUniProt

381 residues, UniProt reviewed canonical sequence.

>P49908|SELENOP
     1  MWRSLGLALA LCLLPSGGTE SQDQSSLCKQ PPAWSIRDQD PMLNSNGSVT VVALLQASUY
    61  LCILQASKLE DLRVKLKKEG YSNISYIVVN HQGISSRLKY THLKNKVSEH IPVYQQEENQ
   121  TDVWTLLNGS KDDFLIYDRC GRLVYHLGLP FSFLTFPYVE EAIKIAYCEK KCGNCSLTTL
   181  KDEDFCKRVS LATVDKTVET PSPHYHHEHH HNHGHQHLGS SELSENQQPG APNAPTHPAP
   241  PGLHHHHKHK GQHRQGHPEN RDMPASEDLQ DLQKKLCRKR CINQLLCKLP TDSELAPRSU
   301  CCHCRHLIFE KTGSAITUQC KENLPSLCSU QGLRAEENIT ESCQURLPPA AUQISQQLIP
   361  TEASASURUK NQAKKUEUPS N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SELENOP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0

Highest tissue expression

5,860 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for SELENOP from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.32

gnomAD pLI

0

DepMap mean gene effect

0

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• brain development
• locomotory behavior
• post-embryonic development
• regulation of growth
• response to oxidative stress
• response to selenium ion
• selenium compound metabolic process

Molecular functions

• selenium binding

Cellular components

• extracellular exosome
• extracellular region
• platelet dense granule lumen

Protein domainsUniProt · Pfam · InterPro

• Selenoprotein P, N-terminal
• Selenoprotein P, C-terminal
• Selenoprotein P
• Selenoprotein P, N terminal region
• Selenoprotein P, C terminal region

KeywordsUniProt

• Glycoprotein
• Phosphoprotein
• Secreted
• Selenium
• Selenocysteine
• Signal