Seroatlas · Human Serome Atlas

SELENOO

Protein adenylyltransferase SelO, mitochondrial

Also known as: SELO, SELO_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BVL4
Gene: SELENOO
Ensembl: ENSG00000073169
Chromosome: 22
Canonical length: 669 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Mitotic chromosome,Mitochondria

OverviewNCBI Gene

This gene encodes a selenoprotein that is localized to the mitochondria. It is the largest mammalian selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The exact function of this selenoprotein is not known, but it is thought to have redox activity. [provided by RefSeq, Dec 2016]

Canonical amino-acid sequenceUniProt

669 residues, UniProt reviewed canonical sequence.

>Q9BVL4|SELENOO
     1  MAVYRAALGA SLAAARLLPL GRCSPSPAPR STLSGAAMEP APRWLAGLRF DNRALRALPV
    61  EAPPPGPEGA PSAPRPVPGA CFTRVQPTPL RQPRLVALSE PALALLGLGA PPAREAEAEA
   121  ALFFSGNALL PGAEPAAHCY CGHQFGQFAG QLGDGAAMYL GEVCTATGER WELQLKGAGP
   181  TPFSRQADGR KVLRSSIREF LCSEAMFHLG VPTTRAGACV TSESTVVRDV FYDGNPKYEQ
   241  CTVVLRVAST FIRFGSFEIF KSADEHTGRA GPSVGRNDIR VQLLDYVISS FYPEIQAAHA
   301  SDSVQRNAAF FREVTRRTAR MVAEWQCVGF CHGVLNTDNM SILGLTIDYG PFGFLDRYDP
   361  DHVCNASDNT GRYAYSKQPE VCRWNLRKLA EALQPELPLE LGEAILAEEF DAEFQRHYLQ
   421  KMRRKLGLVQ VELEEDGALV SKLLETMHLT GADFTNTFYL LSSFPVELES PGLAEFLARL
   481  MEQCASLEEL RLAFRPQMDP RQLSMMLMLA QSNPQLFALM GTRAGIAREL ERVEQQSRLE
   541  QLSAAELQSR NQGHWADWLQ AYRARLDKDL EGAGDAAAWQ AEHVRVMHAN NPKYVLRNYI
   601  AQNAIEAAER GDFSEVRRVL KLLETPYHCE AGAATDAEAT EADGADGRQR SYSSKPPLWA
   661  AELCVTUSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SELENOO can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

liver: 27 nTPM
bone marrow: 13 nTPM
pancreas: 13 nTPM
skeletal muscle: 12 nTPM
cerebellum: 11 nTPM
esophagus: 8 nTPM

Single-cell type

late spermatids: 267 nCPM
hepatocytes: 152 nCPM
proximal tubule cells: 108 nCPM
myonuclei: 105 nCPM
brain excitatory neurons: 79 nCPM
retinal amacrine cells: 74 nCPM

Immune cell

eosinophil: 1.3 nTPM
classical monocyte: 1.1 nTPM
myeloid DC: 1.1 nTPM
MAIT T-cell: 0.5 nTPM
memory CD8 T-cell: 0.5 nTPM
neutrophil: 0.5 nTPM

Brain region

cerebellum: 36 nTPM
cerebral cortex: 26 nTPM
white matter: 24 nTPM
medulla oblongata: 22 nTPM
pons: 20 nTPM
thalamus: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.69
gnomAD pLI: 0
DepMap mean gene effect: -0.04
DepMap dependency class: selective

OntologyGO

Biological processes

protein adenylylation

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Protein adenylyltransferase SelO
Protein adenylyltransferase SelO

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SELENOO as an antibody target. Whether an autoantibody or antibody against SELENOO could matter depends on whether native SELENOO is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SELENOO is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SELENOO as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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