Seroatlas · Human Serome Atlas

SEL1L3

Protein sel-1 homolog 3

Also known as: KIAA0746, SE1L3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q68CR1
Gene: SEL1L3
Ensembl: ENSG00000091490
Chromosome: 4
Canonical length: 1132 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1132 residues, UniProt reviewed canonical sequence.

>Q68CR1|SEL1L3
     1  MQRRGAGLGW PRQQQQQPPP LAVGPRAAAM VPSGGVPQGL GGRSACALLL LCYLNVVPSL
    61  GRQTSLTTSV IPKAEQSVAY KDFIYFTVFE GNVRNVSEVS VEYLCSQPCV VNLEAVVSSE
   121  FRSSIPVYKK RWKNEKHLHT SRTQIVHVKF PSIMVYRDDY FIRHSISVSA VIVRAWITHK
   181  YSGRDWNVKW EENLLHAVAK NYTLLQTIPP FERPFKDHQV CLEWNMGYIW NLRANRIPQC
   241  PLENDVVALL GFPYASSGEN TGIVKKFPRF RNRELEATRR QRMDYPVFTV SLWLYLLHYC
   301  KANLCGILYF VDSNEMYGTP SVFLTEEGYL HIQMHLVKGE DLAVKTKFII PLKEWFRLDI
   361  SFNGGQIVVT TSIGQDLKSY HNQTISFRED FHYNDTAGYF IIGGSRYVAG IEGFFGPLKY
   421  YRLRSLHPAQ IFNPLLEKQL AEQIKLYYER CAEVQEIVSV YASAAKHGGE RQEACHLHNS
   481  YLDLQRRYGR PSMCRAFPWE KELKDKHPSL FQALLEMDLL TVPRNQNESV SEIGGKIFEK
   541  AVKRLSSIDG LHQISSIVPF LTDSSCCGYH KASYYLAVFY ETGLNVPRDQ LQGMLYSLVG
   601  GQGSERLSSM NLGYKHYQGI DNYPLDWELS YAYYSNIATK TPLDQHTLQG DQAYVETIRL
   661  KDDEILKVQT KEDGDVFMWL KHEATRGNAA AQQRLAQMLF WGQQGVAKNP EAAIEWYAKG
   721  ALETEDPALI YDYAIVLFKG QGVKKNRRLA LELMKKAASK GLHQAVNGLG WYYHKFKKNY
   781  AKAAKYWLKA EEMGNPDASY NLGVLHLDGI FPGVPGRNQT LAGEYFHKAA QGGHMEGTLW
   841  CSLYYITGNL ETFPRDPEKA VVWAKHVAEK NGYLGHVIRK GLNAYLEGSW HEALLYYVLA
   901  AETGIEVSQT NLAHICEERP DLARRYLGVN CVWRYYNFSV FQIDAPSFAY LKMGDLYYYG
   961  HQNQSQDLEL SVQMYAQAAL DGDSQGFFNL ALLIEEGTII PHHILDFLEI DSTLHSNNIS
  1021  ILQELYERCW SHSNEESFSP CSLAWLYLHL RLLWGAILHS ALIYFLGTFL LSILIAWTVQ
  1081  YFQSVSASDP PPRPSQASPD TATSTASPAV TPAADASDQD QPTVTNNPEP RG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SEL1L3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 120 nTPM

Expression across tissuesHPA

Tissue

tonsil: 120 nTPM
lymph node: 117 nTPM
stomach: 99 nTPM
duodenum: 77 nTPM
small intestine: 68 nTPM
colon: 68 nTPM

Single-cell type

pdcs: 688 nCPM
plasma cells: 640 nCPM
b-cells: 604 nCPM
foveolar cells: 252 nCPM
transitional alveolar cells: 246 nCPM
mucous neck cells: 235 nCPM

Immune cell

memory B-cell: 42 nTPM
naive B-cell: 42 nTPM
plasmacytoid DC: 38 nTPM
T-reg: 9.6 nTPM
NK-cell: 8.1 nTPM
memory CD4 T-cell: 7 nTPM

Brain region

cerebellum: 176 nTPM
cerebral cortex: 30 nTPM
basal ganglia: 25 nTPM
choroid plexus: 23 nTPM
thalamus: 22 nTPM
hippocampal formation: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.42
gnomAD pLI: 0
gnomAD missense Z: 1.3
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Sel1-like repeat
Tetratricopeptide-like helical domain superfamily
Concanavalin A-like lectin/glucanase domain superfamily
Sel1 repeat
Protein sel-1 homolog 3

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SEL1L3 as an antibody target. Whether an autoantibody or antibody against SEL1L3 could matter depends on whether native SEL1L3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SEL1L3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SEL1L3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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