Seroatlas · Human Serome Atlas

SEL1L2

Protein sel-1 homolog 2

Also known as: C20orf50, DKFZp434C1826, SE1L2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5TEA6
Gene: SEL1L2
Ensembl: ENSG00000101251
Chromosome: 20
Canonical length: 688 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in ERAD pathway. Located in cilium and nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

688 residues, UniProt reviewed canonical sequence.

>Q5TEA6|SEL1L2
     1  MKPLSLLIEI LIILGVTIKT IKAEEHNKRQ KERNVTTQVS VNEIKQYLSH ILEQRTSSNV
    61  INKRENLLEK KKNQRKIRIK GIQNKDILKR NKNHLQKQAE KNFTDEGDQL FKMGIKVLQQ
   121  SKSQKQKEEA YLLFAKAADM GNLKAMEKMA DALLFGNFGV QNITAAIQLY ESLAKEGSCK
   181  AQNALGFLSS YGIGMEYDQA KALIYYTFGS AGGNMMSQMI LGYRYLSGIN VLQNCEVALS
   241  YYKKVADYIA DTFEKSEGVP VEKVRLTERP ENLSSNSEIL DWDIYQYYKF LAERGDVQIQ
   301  VSLGQLHLIG RKGLDQDYYK ALHYFLKAAK AGSANAMAFI GKMYLEGNAA VPQNNATAFK
   361  YFSMAASKGN AIGLHGLGLL YFHGKGVPLN YAEALKYFQK AAEKGWPDAQ FQLGFMYYSG
   421  SGIWKDYKLA FKYFYLASQS GQPLAIYYLA KMYATGTGVV RSCRTAVELY KGVCELGHWA
   481  EKFLTAYFAY KDGDIDSSLV QYALLAEMGY EVAQSNSAFI LESKKANILE KEKMYPMALL
   541  LWNRAAIQGN AFARVKIGDY HYYGYGTKKD YQTAATHYSI AANKYHNAQA MFNLAYMYEH
   601  GLGITKDIHL ARRLYDMAAQ TSPDAHIPVL FAVMKLETTH LLRDILFFNF TTRWNWLKLD
   661  NTIGPHWDLF VIGLIVPGLI LLLRNHHG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SEL1L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 6.6 nTPM

Expression across tissuesHPA

Tissue

testis: 6.6 nTPM
basal ganglia: 0.1 nTPM
endometrium: 0.1 nTPM
fallopian tube: 0.1 nTPM
ovary: 0.1 nTPM
smooth muscle: 0.1 nTPM

Single-cell type

late spermatids: 241 nCPM
late primary spermatocytes: 196 nCPM
early spermatids: 191 nCPM
cardiomyocytes: 118 nCPM
epicardial cells: 50 nCPM
early primary spermatocytes: 28 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 2.5 nTPM
cerebellum: 1.4 nTPM
hypothalamus: 1.4 nTPM
cerebral cortex: 1.1 nTPM
amygdala: 0.9 nTPM
medulla oblongata: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0
gnomAD missense Z: 0.27
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

ERAD pathway

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SEL1L2 as an antibody target. Whether an autoantibody or antibody against SEL1L2 could matter depends on whether native SEL1L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SEL1L2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SEL1L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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